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Exploration of Targeted Anti-tumor Therapy, 2021 Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherapeutic drug used to treat TNBC is doxorubicin (Doxo) which
Garhima Arora +2 more
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Scientific Reports, 2021 Research on new cancer drugs is performed either through gene knockout studies or phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and time-consuming.
Abhijit Paul +5 more
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To cluster, or not to cluster: An analysis of clusterability methods [PDF]
Pattern Recognition, 2019 Clustering is an essential data mining tool that aims to discover inherent cluster structure in data. For most applications, applying clustering is only appropriate when cluster structure is present. As such, the study of clusterability, which evaluates whether data possesses such structure, is an integral part of cluster analysis. However, methods for
Andreas Adolfsson +2 more
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Survival cluster analysis [PDF]
Proceedings of the ACM Conference on Health, Inference, and Learning, 2020 Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown) subpopulations with diverse risk profiles or survival distributions. As a result, there is an unmet need in survival
Paidamoyo Chapfuwa +4 more
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Coral endosymbiont growth is enhanced by metabolic interactions with bacteria
Nature Communications, 2023 Bacteria are key contributors to microalgae resource acquisition, competitive performance, and functional diversity, but their potential metabolic interactions with coral microalgal endosymbionts (Symbiodiniaceae) have been largely overlooked.
Jennifer L. Matthews +10 more
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Population density and energy consumption: A study in Indonesian provinces
Heliyon, 2022 As the world’s fourth most populous country, the population growth rate in Indonesia is expected to stay high. Owing to a combination of high-speed urbanization and increasing population density, economic growth is predicted to increase the demand for ...
Irfani Fithria Ummul Muzayanah +4 more
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Coming home to die? The association between migration and mortality in rural Tanzania before and after ART scale-up [PDF]
Global Health Action, 2014 Background: Prior to the scale-up of antiretroviral therapy (ART), demographic surveillance cohort studies showed higher mortality among migrants than residents in many rural areas.
Francis Levira +2 more
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Frontiers in Cell and Developmental Biology, 2022 “Trim-Away” technology enables rapid degradation of endogenous proteins without prior modification of protein-coding genes or mRNAs through delivery of antibodies that target proteins of interest.
Rina Kunishige +6 more
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Detection and analysis of cluster–cluster filaments [PDF]
Monthly Notices of the Royal Astronomical Society, 2020 ABSTRACTIn this work, we identify and analyse the properties of cluster–cluster filaments within a cosmological simulation assuming that they are structures connecting maxima of the density field defined by dark matter haloes with masses $M \, \ge 10^{14}\, h^{-1} \, \mathrm{M_{\odot }}$.
Luis A Pereyra +4 more
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, 2000 As an explorative technique, duster analysis provides a description or a reduction in the dimension of the data. It classifies a set of observations into two or more mutually exclusive unknown groups based on combinations of many variables. Its aim is to construct groups in such a way that the profiles of objects in the same groups are relatively ...
Mucha, Hans-Joachim, Sofyan, Hizir
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