Results 51 to 60 of about 1,519,867 (319)

Unlocking the potential of computational phenotypic drug discovery: methods, challenges, and future directions

npj Systems Biology and Applications
Phenotypic drug discovery (PDD) identifies new drugs by observing the effects of compounds on living systems without prior knowledge of their targets. Advances in biological data and machine learning have made PDD more systematic and data-driven.
Shivam Kumar, Aman Pal, Samrat Chatterjee   +2 more
doaj   +1 more source

konnect2prot 2.0: Integrating advanced analytical tools for deeper understanding of protein properties in a functional protein-protein interaction network

Computational and Structural Biotechnology Journal
Proteins work in coordination to catalyze and regulate all biological activities and drive cellular functions. The collective behavior of proteins is studied through protein-protein interaction (PPI) networks, which provide a system-level understanding ...
Shivam Kumar, Abhinav Agarwal, Dipanka Tanu Sarmah, Samrat Chatterjee   +3 more
doaj   +1 more source

Use of Principal Component Analysis and Cluster Analysis for Differentiation of Traditionally-Manufactured Vinegars Based on Phenolic and Volatile Profiles, and Antioxidant Activity

Polish Journal of Food and Nutrition Sciences, 2020
This study aimed to characterize twelve vinegar samples produced by the traditional method with the use of whole fruits and without any preservatives in terms of their physicochemical properties, total phenolic content (TPC), total flavonoid content (TFC)
Ayse Karadag, Fatih Bozkurt, Hatice Bekiroglu, Osman Sagdic   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

CERNatschool/fast-cluster-analysis: Initial official version (v2.0) - updated for IRIS.

, 2017
<p>This code can be used to perform a "fast" cluster analysis on data collected with a Timepix detector for use in research conducted as part of the CERN@school programme. An example analysis using the radiation profile methods described in Section
Tom Whyntie
core   +1 more source

Symplectic Maps from Cluster Algebras [PDF]

, 2011
We consider nonlinear recurrences generated from the iteration of maps that arise from cluster algebras. More precisely, starting from a skew-symmetric integer matrix, or its corresponding quiver, one can define a set of mutation operations, as well as a
Fordy, Allan P., Allan P. Fordy, Andrew Hone, Hone, Andrew N.W.   +3 more
core   +1 more source

Exploring the determinants of energy poverty in Indonesia’s households: empirical evidence from the 2015–2019 SUSENAS

Humanities & Social Sciences Communications
This study explores the determinants of household-level energy poverty in Indonesia by using highly granular, household-level socioeconomic data on Indonesia from the 2015–2019 National Socioeconomic Survey (SUSENAS).
Novani Karina Saputri, Lourentius Dimas Setyonugroho, Djoni Hartono   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Initial Cluster Analysis [PDF]

Journal of Computational Biology, 2018
We study a simple abstract problem motivated by a variety of applications in protein sequence analysis. Consider a string of 0s and 1s of length L, and containing D 1s. If we believe that some or all of the 1s may be clustered near the start of the sequence, which subset is the most significantly so clustered, and how significant is this clustering? We
Stephen F. Altschul, Andrew F. Neuwald
openaire   +2 more sources