Results 241 to 250 of about 4,646,261 (335)

Multi-Factor Cost Function-Based Interference-Aware Clustering with Voronoi Cell Partitioning for Dense WSNs. [PDF]

Sensors (Basel)
Sam Peter S, Jayarajan P, Maheswar R, Maheswaran S.   +3 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Energy-efficient wireless sensor network for urban groundwater level monitoring using machine learning and sink mobility. [PDF]

Sci Rep
Manchanda R, Lakshmi AV, Kaur G, Sudhamsu G, Samal SK, Jebaselvi GDA, Kumar R, Bhowmik A, Ashok N.   +8 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

A bioinformatics analysis revealing autophagy related DEGs in head and neck squamous cell carcinoma: expanding insights into lipid metabolism. [PDF]

Braz J Otorhinolaryngol
Cheng Y, Li X.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Developing objective tools to study rock hyrax (Procavia capensis) behaviour in the field. [PDF]

PLoS One
Brotier H, Alba-Gonzalez P, Kannan P, Geffen E, Ilany A, Koren L.   +5 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

The Leadership Perception Gap in Spanish Anesthesiology Departments: A National Cross-Sectional Survey Comparing Department Heads and Staff Views. [PDF]

J Healthc Leadersh
Poves-Álvarez R, Gómez-Sánchez E, Martínez-Rafael B, Lorenzo-López M, Rodríguez-Cerón G, Gómez-Pesquera E, López-Herrero R, Arranz-Molinero E, Vaquerizo-Villar F, Hornero R, Gavilan D, Tamayo E.   +11 more
europepmc   +1 more source