Results 71 to 80 of about 1,060,459 (257)
Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients
Annals of Neurology, EarlyView.Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer +14 more
wiley +1 more source
, 2021 Chronic cluster headache (CCH) often resists to prophylactic pharmaceutical treatments resulting in patients' life damage. In this rare but pragmatic situation escalation to invasive management is needed but framing criteria are lacking.
Martelletti, Paolo +21 more
core +1 more source
Annals of Neurology, EarlyView.Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate +34 more
wiley +1 more source
, 2015 Background: Very few qualitative studies on cluster headache have been conducted. As a result we have little in-depth understanding of the perceptions and experiences of cluster headache patients and the health professionals who treat them.
Ahmed, F. +4 more
core
Transcranial Doppler study in patients with cluster headache
Alexandria Journal of Medicine, 2013 Background: Hemodynamic changes occur in the cerebral blood flow during cluster headache. Objective: The aim of the present work was to study the middle cerebral artery blood flow velocities and vasoreactivity in cluster headache patients as baseline ...
Soleiman A.M. Tahoon +3 more
doaj +1 more source
Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology
Annals of Neurology, EarlyView.Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko +8 more
wiley +1 more source
Differences of Cluster Headache on the Basis of Sex in the Korean Cluster Headache Registry
, 2019 Background: Most of the clinical characteristics of cluster headache (CH) have been established through the observation of men with CH. Epidemiological data of CH in women are scarce especially in the Asian population.
주민경
core +1 more source
Annals of Neurology, EarlyView.Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola +14 more
wiley +1 more source
Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
The Journal of Headache and PainBackground New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies.
Ioana Medrea +4 more
doaj +1 more source
Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology
Annals of Neurology, EarlyView.Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby +6 more
wiley +1 more source