Results 201 to 210 of about 9,834 (312)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Looking inwards and looking outwards – specific challenges and strategic directions from the prohibition of cluster munitions

, 2010
Brian Rappert, Richard Moyes
openalex   +2 more sources

Neurotoxicology of warfare arsenical, diphenylarsinic acid in humans and experimental models. [PDF]

Chemosphere
Saggu S, Srivastava RK, McCormick L, Agarwal A, Khan MM, Athar M.   +5 more
europepmc   +1 more source

MELEGROS: Monolithic Elephant‐Inspired Gripper with Optical Sensors

Advanced Science, EarlyView.
MELEGROS is a monolithic, elephant‐inspired soft gripper integrating 3D‐printed optical sensors within a pneumatically actuated lattice. Simulation‐guided design decouples tactile and proprioceptive sensing. Characterized through grasping tests, MELEGROS can reach, scoop, and grasp, showcasing a paradigm where fully embedded sensing and continuous ...
Petr Trunin, Diana Cafiso, Anderson Brazil Nardin, Trevor Exley, Lucia Beccai   +4 more
wiley   +1 more source

Phylogenetic analysis of microbial CP-lyase cluster genes for bioremediation of phosphonate. [PDF]

AMB Express
Richard PI, Baltosser WH, Williams PH, He Q.   +3 more
europepmc   +1 more source

Failure to protect: a case for the prohibition of cluster munitions

, 2006
Brian Rappert, R.B. Moyes
openalex   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Thermal Decomposition of Core-Shell-Structured RDX@AlH₃, HMX@AlH₃, and CL-20@AlH₃ Nanoparticles: Reactive Molecular Dynamics Simulations. [PDF]

Nanomaterials (Basel)
Sun Z, Yang L, Li H, Mei M, Ye L, Fan J, Zhu W.   +6 more
europepmc   +1 more source

Les Armes à Sous-Munitions en Droit International Humanitaire: Enjeux et Défis de Leur Interdiction (Cluster Munitions in International Humanitarian Law: Issues Surrounding Their Prohibition)

, 2011
Annyssa Bellal, Stuart Casey-Maslen
openalex   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source