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Group sequential designs for stepped-wedge cluster randomised trials. [PDF]
Clinical Trials, 2017 BACKGROUND/AIMS: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster ...
Grayling, Michael J +2 more
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Cluster randomised trials [PDF]
Epidemiology and Psychiatric Sciences, 2011 Although randomised controlled trials are the reference methodology to assess the effects of therapeutic interventions, for interventions that naturally occur in groups of individuals random allocation of participants may be inappropriate. In these cases, the unit of random allocation may be the group or cluster, rather than the individual.
BARBUI, Corrado, CIPRIANI, Andrea
openaire +4 more sources
Methodological bias in cluster randomised trials [PDF]
BMC Medical Research Methodology, 2005 Abstract Background Cluster randomised trials can be susceptible to a range of methodological problems. These problems are not commonly recognised by many researchers. In this paper we discuss the issues that can lead to bias in cluster trials. Methods
Hahn, Seokyung +3 more
openaire +5 more sources
How to design efficient cluster randomised trials [PDF]
BMJ, 2017 Cluster randomised trials have diminishing returns in power and precision as cluster size increases. Making the cluster a lot larger while keeping the number of clusters fixed might yield only a very small increase in power and precision, owing to the intracluster correlation.
Hemming, K +4 more
openaire +3 more sources
Trials, 2018 Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström +4 more
doaj +1 more source
Resuscitation Plus, 2022 Aims: The Prehospital Optimal Shock Energy for Defibrillation (POSED) study will assess the feasibility of conducting a cluster randomised controlled study of clinical effectiveness in UK ambulance services to identify the optimal shock energy for ...
Helen Pocock +9 more
doaj +1 more source
Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals [PDF]
, 2003 Objective To examine the prevalence of a risk of bias associated with the design and conduct of cluster randomised controlled trials among a sample of recently published studies.
Puffer, S, Torgerson, D J, Watson, J
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Analysis of a trial randomised in clusters [PDF]
BMJ, 1998 A cluster randomised study is one where a group of subjects are randomised to the same treatment together—for example, when women in some districts are offered breast cancer screening and compared with women in other districts, or when the patients of general practitioners who have been given special training are compared with the patients of those who
S M, Kerry, J M, Bland
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Health facility utilisation changes during the introduction of community case management of malaria in South Western Uganda: An interrupted time series approach. [PDF]
, 2015 This dataset contains all visits made to health facilities in Bwambara Sub-county, South Western Uganda as part of a cluster randomised trial.
Alexander, Neal +7 more
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Friendship Bench trial: lay worker training in problem-solving therapy to reduce symptoms of common mental disorders [PDF]
, 2015 The Friendship Bench trial is a cluster-randomised trial of the effect of problem-solving therapy training for lay workers on symptoms of common mental disorders among clinic attenders in Harare, Zimbabwe. This dataset enables replication of analysis for
Abas, Melanie +13 more
core +1 more source