Results 21 to 30 of about 177,882 (303)

Contamination in complex healthcare trials:the falls in care homes (FinCH) study experience [PDF]

, 2020
BACKGROUND: Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention.
Allen, F, Darby, J, Fox, C, Gordon, A L, Horne, J C, Leighton, P, Logan, P A, Robinson, K, Sims, Erika   +8 more
core   +1 more source

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study.

PLoS ONE, 2021
BackgroundPeople with cancer often have unidentified symptoms and social care needs. The Needs Assessment Tool-Cancer (NAT-C) is a validated, structured method of assessing patient/carer concerns and prompting action, to address unmet need.AimsAssess ...
Joseph Clark, Elvis Amoakwa, Alexandra Wright-Hughes, John Blenkinsopp, David C Currow, David Meads, Amanda Farrin, Victoria Allgar, Una Macleod, Miriam Johnson   +9 more
doaj   +1 more source

Determining the sample size for a cluster-randomised trial: Bayesian hierarchical modelling of the ICC estimate [PDF]

, 2015
In common with many cluster-randomised trials, it was difficult to determine the appropriate sample size for the planned trial of the effectiveness of a systematic voiding programme for post-stroke incontinence due to the lack of a robust estimate of the
Leathley, Michael John, Sutton, Chris J, Thomas, Lois Helene, Tishkovskaya, Svetlana, Watkins, Caroline Leigh   +4 more
core   +1 more source

Ethical implications of excessive cluster sizes in cluster randomised trials [PDF]

BMJ Quality & Safety, 2018
The cluster randomised trial (CRT) is commonly used in healthcare research. It is the gold-standard study design for evaluating healthcare policy interventions. A key characteristic of this design is that as more participants are included, in a fixed number of clusters, the increase in achievable power will level off.
Karla Hemming, Monica Taljaard, Gordon Forbes, Sandra M Eldridge, Charles Weijer   +4 more
openaire   +3 more sources

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial [PDF]

, 2016
Background: Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death.
Adamson, Ashley, Barnes, Alison, Brosnahan, Naomi, Ford, Ian, Hollingsworth, Kieren G., Kean, Sharon, Lean, Mike E.J., Leslie, Wilma S., Mathers, John C., McCombie, Louise, McIlvenna, Yvonne, Peters, Carl, Rehackova, Lucia, Rodrigues, Angela, Ross, Hazel, Sattar, Naveed, Sniehotta, Falko F., Taylor, Roy, Thom, George, Zhyzhneuskaya, Sviatlana   +19 more
core   +3 more sources

Activities to support the implementation of complex interventions as part of routine care: a review of the quality of reporting in cluster randomised controlled trials [PDF]

, 2015
Objective: To review a sample of cluster randomised controlled trials and explore the quality of reporting of (1) enabling or support activities provided to the staff during the trial, (2) strategies used to monitor fidelity throughout the trial and (3 ...
Boutron, Campbell, Chalmers, Chan, Craig, Douet, Flay, Gartlehner, Glasgow, Glasziou, Hoffmann, Hoffmann, Moore, Papadakis, Schroter, Schulz, Thorpe, Wells   +17 more
core   +2 more sources

The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs. [PDF]

, 2017
Background/Aims We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs.
Copas, Andrew, Fielding, Katherine, Hargreaves, James, Thompson, Jennifer A   +3 more
core   +2 more sources

Data for Thinking Healthy Programme Pakistan trial (THPP-Pakistan) [PDF]

, 2018
An anonymised dataset of 570 women (one row per woman) who gave informed consent to participate in a cluster randomised, parallel, superiority, controlled trial in Rawalpindi, Pakistan in 2014-2017. The intervention was an adapted version of the Thinking
Ahmad, Ikhlaq, Fuhr, Daniela, Patel, Vikram, Rahman, Atif, Sikander, Siham, Vanobberghen, Fiona, Weiss, Helen, Zaidi, Ahmed   +7 more
core   +1 more source

Does a pre-hospital emergency pathway improve early diagnosis and referral in suspected stroke patients? – Study protocol of a cluster randomised trial [ISRCTN41456865]

BMC Health Services Research, 2005
Background Early interventions proved to be able to improve prognosis in acute stroke patients. Prompt identification of symptoms, organised timely and efficient transportation towards appropriate facilities, become essential part of effective treatment.
Lori Giuliano, Rossi Paolo, De Luca Assunta, Ferri Marica, Guasticchi Gabriella   +4 more
doaj   +1 more source

Feasibility of testing the effectiveness of a theory-informed intervention to reduce imaging for low back pain: a pilot cluster randomised controlled trial

Pilot and Feasibility Studies, 2022
Background General medical practitioner (GP) recruitment and subsequent data collection in clinical practice are challenging and may limit successful completion of a large-scale trial.
Hazel J. Jenkins, Simon D. French, Anika Young, Niamh A. Moloney, Chris G. Maher, John S. Magnussen, Blake F. Dear, Mark J. Hancock   +7 more
doaj   +1 more source