Results 81 to 90 of about 177,882 (303)

Setting priorities to inform assessment of care homes’ readiness to participate in healthcare innovation: a systematic mapping review and consensus process [PDF]

, 2020
© 2020 The Author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedOrganisational ...
Bunn, F., Corazzini, K., Dening, T., Goodman, C., Gordon, A. L., Handley, M., Lynch, J, Meyer, J., Sharpe, R.   +8 more
core   +4 more sources

A brief history of the cluster randomised trial design [PDF]

Journal of the Royal Society of Medicine, 2015
The cluster randomised trial is commonly considered a relatively new research study design.1–3 Here we trace to a few very early reports the idea of comparing interventions applied to groups of individuals, and through the evolution of this idea to the modern-day cluster randomised trial.
Jenny, Moberg, Michael, Kramer
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
A Donner, AJ Bellg, AJ Engers, Australian Acute Musculoskeletal Pain Guidelines Group (AAMPGG), B McGuirk, BF Walker, BF Walker, BS Frankel, C Bombardier, C Bombardier, D Di Iorio, D Mortimer, Denise A O'Connor, DG Altman, DG Altman, DK Freeborn, Duncan Mortimer, DW King, DW King, EM Hay, FB Hu, G Waddell, GM Fitzmaurice, H Britt, H Schers, J Francis, J Mollison, J Zhang, Jeremy M Grimshaw, Jill Francis, JJ Yallop, JM Grimshaw, JM Neuhaus, JM Schectman, Joanne E McKenzie, M Campbell, M Eccles, M Roland, M Roland, M Von Korff, MK Campbell, MR Robling, N Klar, Neil Spike, NJ Horton, OC Ukoumunne, P Dey, P Little, P Oakeshott, PB Bishop, Peter M Kent, Peter Schattner, PJ Diggle, PM Kent, R Buchbinder, R Buchbinder, R Buchbinder, R Buchbinder, R Grol, Rachelle Buchbinder, S Hakkennes, S Hollis, S Kerry, S Michie, Sally E Green, Simon D French, SJ Pocock, SJ Senn, SR Heritier, Susan Michie, SZ George, T Permutt, TS Carey, V Gonzalez-Urzelai, W Hardeman   +74 more
core   +4 more sources

Assessing potential sources of clustering in individually randomised trials [PDF]

BMC Medical Research Methodology, 2013
Recent reviews have shown that while clustering is extremely common in individually randomised trials (for example, clustering within centre, therapist, or surgeon), it is rarely accounted for in the trial analysis. Our aim is to develop a general framework for assessing whether potential sources of clustering must be accounted for in the trial ...
Kahan, BC, Morris, TP
openaire   +4 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Effectiveness of continence promotion for older women via community organisations: A cluster randomised trial [PDF]

, 2013
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative ...
Agnew, R, Benedetti, A, Tannenbaum, C, Thomas, D, van den Heuvel, E   +4 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Evaluation of a medication monitor-based treatment strategy for drug-sensitive tuberculosis patients in China: study protocol for a cluster randomised controlled trial

Trials, 2018
Background Treatment for drug-sensitive tuberculosis (TB) is taken for at least 6 months and problems with adherence are common. Therefore, there is substantial interest in the possible use of eHealth interventions to support patients to take their ...
James J. Lewis, Xiaoqiu Liu, Zhiying Zhang, Bruce V. Thomas, Anna Vassall, Sedona Sweeney, Xu Caihong, Hu Dongmei, Li Xue, Gao Yongxin, Shitong Huan, Jiang Shiwen, Katherine L. Fielding   +12 more
doaj   +1 more source

Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: Screening versus routine practice in detection cluster randomised controlled trial [PDF]

, 2007
Objectives : To assess whether screening improves the detection of atrial fibrillation (cluster randomisation) and to compare systematic and opportunistic screening.
Allan, T.F., Bryan, S., Davies, M., Fitzmaurice, D.A., Hobbs, F.D.R., Holder, R.L., Jowett, S.M., Lip, G.Y.H., Mant, J.W.F., Murray, E.T., Raftery, J.P.   +10 more
core