Results 81 to 90 of about 175,554 (303)

A brief history of the cluster randomised trial design [PDF]

Journal of the Royal Society of Medicine, 2015
The cluster randomised trial is commonly considered a relatively new research study design.1–3 Here we trace to a few very early reports the idea of comparing interventions applied to groups of individuals, and through the evolution of this idea to the modern-day cluster randomised trial.
Jenny, Moberg, Michael, Kramer
openaire   +2 more sources

Insecticide-treated nets for the prevention of malaria in pregnancy: a systematic review of randomised controlled trials.

PLoS Medicine, 2007
BackgroundProtection from malaria with insecticide-treated bednets (ITNs) during pregnancy is widely advocated, but evidence of benefit has been inconsistent.
Carol Gamble, Paul J Ekwaru, Paul Garner, Feiko O ter Kuile   +3 more
doaj   +1 more source

Embedded motivational interviewing combined with a smartphone app to increase physical activity in people with sub-acute low back pain: study protocol of a cluster randomised control trial [PDF]

, 2019
Background: Motivational Interviewing is an evidence-based, client-centred counselling technique that has been used effectively to increase physical activity, including for people with low back pain.
Breckon, Jeff, Davidson, M, Holden, J, Monfries, M, O’ Halloran, PD, Rahayu, W, Taylor, NF   +6 more
core   +2 more sources

Assessing potential sources of clustering in individually randomised trials [PDF]

BMC Medical Research Methodology, 2013
Recent reviews have shown that while clustering is extremely common in individually randomised trials (for example, clustering within centre, therapist, or surgeon), it is rarely accounted for in the trial analysis. Our aim is to develop a general framework for assessing whether potential sources of clustering must be accounted for in the trial ...
Kahan, BC, Morris, TP
openaire   +4 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: Screening versus routine practice in detection cluster randomised controlled trial [PDF]

, 2007
Objectives : To assess whether screening improves the detection of atrial fibrillation (cluster randomisation) and to compare systematic and opportunistic screening.
Allan, T.F., Bryan, S., Davies, M., Fitzmaurice, D.A., Hobbs, F.D.R., Holder, R.L., Jowett, S.M., Lip, G.Y.H., Mant, J.W.F., Murray, E.T., Raftery, J.P.   +10 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The combined diabetes and renal control trial (C-DIRECT) - a feasibility randomised controlled trial to evaluate outcomes in multi-morbid patients with diabetes and on dialysis using a mixed methods approach [PDF]

, 2019
Background: This cluster randomised controlled trial set out to investigate the feasibility and acceptability of the “Combined Diabetes and Renal Control Trial” (C-DIRECT) intervention, a nurse-led intervention based on motivational interviewing and self-
AM Jacobson, AS Zigmond, AY Lai, C. G. Chua, CA Eigenmann, CSY Goh, DJ Toobert, E Salsberg, E. Y. H. Khoo, EA Bayliss, EA Beverly, EA Kerr, F Willingham, GW Welch, H Knight, H Vlaminck, I Bjelland, IM Stratton, IR White, JY Chen, K Griva, K. Griva, KR Lorig, L Bramley, M Anees, M. Nandakumar, M. Rajeswari, MA Powers, ME Charlson, MF Huang, MJ Davies, P Craig, R Schwarzer, RD Hays, RH Osborne, RK Yoong, S Newman, S. P. Newman, SL Norris, T Washington, V Braun, V. Y. W. Lee, WH Polonsky, Y-Q Huang, Y. T. D. Choong, YH Tang, Z. S. Goh   +46 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evaluation of a medication monitor-based treatment strategy for drug-sensitive tuberculosis patients in China: study protocol for a cluster randomised controlled trial

Trials, 2018
Background Treatment for drug-sensitive tuberculosis (TB) is taken for at least 6 months and problems with adherence are common. Therefore, there is substantial interest in the possible use of eHealth interventions to support patients to take their ...
James J. Lewis, Xiaoqiu Liu, Zhiying Zhang, Bruce V. Thomas, Anna Vassall, Sedona Sweeney, Xu Caihong, Hu Dongmei, Li Xue, Gao Yongxin, Shitong Huan, Jiang Shiwen, Katherine L. Fielding   +12 more
doaj   +1 more source