Results 101 to 110 of about 795,774 (269)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Unveiling sub-populations in critical care settings: a real-world data approach in COVID-19

Frontiers in Public Health
BackgroundDisease presentation and progression can vary greatly in heterogeneous diseases, such as COVID-19, with variability in patient outcomes, even within the hospital setting.
Wesley Anderson, Ruth Gould, Namrata Patil, Nicholas Mohr, Kenneth Dodd, Danielle Boyce, Danielle Boyce, Pam Dasher, Philippe J. Guerin, Reham Khan, Sreekanth Cheruku, Vishakha K. Kumar, Ewy Mathé, Aneesh K. Mehta, Andrew P. Michelson, Andrew Williams, Smith F. Heavner, Smith F. Heavner, Smith F. Heavner, Jagdeep T. Podichetty   +19 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance

Frontiers in Psychology
IntroductionLifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognitive trajectories
Alba Roca-Ventura, Alba Roca-Ventura, Alba Roca-Ventura, Javier Solana-Sánchez, Javier Solana-Sánchez, Javier Solana-Sánchez, Gabriele Cattaneo, Gabriele Cattaneo, Gabriele Cattaneo, Vanessa Alviarez-Schulze, Vanessa Alviarez-Schulze, Vanessa Alviarez-Schulze, Goretti España-Irla, Goretti España-Irla, Goretti España-Irla, María Redondo-Camós, María Redondo-Camós, María Redondo-Camós, Selma Delgado-Gallén, Selma Delgado-Gallén, Selma Delgado-Gallén, Ruben Romero, Ruben Romero, Ruben Romero, Edgar Buloz-Osorio, Edgar Buloz-Osorio, Edgar Buloz-Osorio, Álvaro Pascual-Leone, Álvaro Pascual-Leone, David Bartrés-Faz, David Bartrés-Faz, David Bartrés-Faz   +31 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A COMPARATIVE ANALYSIS OF DBSCAN AND GAUSSIAN MIXTURE MODEL FOR CLUSTERING INDONESIAN PROVINCES BASED ON SOCIOECONOMIC WELFARE INDICATORS

Barekeng
Public welfare refers to a condition in which people experience happiness, comfort, prosperity, and can adequately fulfill their basic needs. Indonesia consists of several provinces, each with varying levels of welfare.
Sri Andayani, Namita Retnani, Thesa Adi Saputra Yusri, Bambang Sumarno Hadi Marwoto   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source