Overcoming Gastric Barriers for Oral Peptide Delivery: QbD-Based Development of Sodium Caprate-Enabled Tirzepatide Tablets. [PDF]
Im S, Lee JY, Kim JE.
europepmc +1 more source
This study reviews the first eight NDC3 submissions (Zambia, Zimbabwe, Lesotho, Japan, New Zealand, Canada, the United Kingdom, and Switzerland), comparing reference points, timeframes, scope, methodologies, ambition, and adaptation indicators. Results show strong mitigation ambition in developed countries but persistent adaptation and implementation ...
Samwel Manyele, Honest Anicetus
wiley +1 more source
Exploring electron spin dynamics in spin chains using defects as a quantum probe. [PDF]
Soriano L +9 more
europepmc +1 more source
DreamFold: A World Model to efficiently generate protein folding pathways in the latent space
Abstract While there is an abundance of static data for the structure of biological macromolecules, the data regarding their folding mechanisms and dynamics is scarce, posing a challenge to the training of AI models. The World Model approach, which has been very successful in robotics, can come in handy in this regard. From limited data, it can build a
Alan Ianeselli +3 more
wiley +1 more source
ABSTRACT Objective This study aimed to evaluate the impact of pathogenic genetic variants on growth outcomes following 3 years of recombinant human growth hormone (rhGH) therapy in children born small for gestational age with persistent short stature (SGA‐SS). Design A retrospective cohort study.
Sanghee Park +15 more
wiley +1 more source
Prevalence of Phelan McDermid Syndrome Estimated To Be ~1:7300 Using a Multisource Model. [PDF]
Levy T +9 more
europepmc +1 more source
Nickel‐Substituted Rubredoxin Undergoes Demetallation Upon Reaction With Nitric Oxide and Nitroxyl
Rubredoxin is a thermally stable thiolate iron‐bound protein that can be prepared as a nickel‐substituted one. This nickel protein showed sensitivity to reaction with NO and HNO donors, causing its demetallation. Notably, these reactions exhibit spectroscopic profiles in the ultraviolet–visible and fluorescence with potential bioanalytical use.
Eduardo H. S. Sousa +8 more
wiley +1 more source
Analytical Quality by Design-Based Reverse-Phase High-Performance Liquid Chromatography Method Development for Biomarker: A Comprehensive Review of Quality Assessment and Analytical Trends. [PDF]
Patil SB, Sutar SB, Bhimanwar R.
europepmc +1 more source
openaire +1 more source
Neutrophil activation in juvenile dermatomyositis: associations with muscle function and disease progression. [PDF]
Shi J +9 more
europepmc +1 more source

