Results 101 to 110 of about 72,198 (215)

Myelofibrosis predicts deep molecular response 4.5 in chronic myeloid leukaemia patients initially treated with imatinib: An extensive, multicenter and retrospective study to develop a prognostic model

open access: yesClinical and Translational Medicine
Tian Zeng   +51 more
doaj   +1 more source

Composite marginal likelihood estimation of higher‐order diagnostic classification models under high dimensionality

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Although full‐information maximum likelihood (FIML) estimation is widely used for diagnostic classification models (DCMs), its computational efficiency deteriorates sharply in high‐dimensional settings. This scalability challenge is increasingly critical as DCMs are applied to large‐scale assessments, psychological testing and longitudinal ...
Minho Lee, Yon Soo Suh
wiley   +1 more source

Targeting KRAS for cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia   +4 more
wiley   +1 more source

Symptom burden in myeloproliferative neoplasms: clinical correlates, dynamics, and survival impact—a study of 784 patients from the Quebec MPN research group

open access: yesBlood Cancer Journal
Alisa Poullet   +13 more
doaj   +1 more source

A fatal posterior-fossa chloroma masquerading as tuberculous meningitis after peripartum BCR-ABL1 inhibitor cessation - a case report. [PDF]

open access: yesLeuk Res Rep
Zutshi B   +8 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira   +3 more
wiley   +1 more source

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