Results 241 to 250 of about 216,439 (378)

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, EarlyView.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

The disease‐linked R336C mutation in cystathionine β‐synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

The FEBS Journal, EarlyView.
Cystathionine β‐synthase (CBS) is an essential enzyme involved in cysteine metabolism. The mutation R336C, associated with severe homocystinuria and of high incidence in Qatar, reduces its activity. Our research shows that this mutation does not destabilize the enzyme fold but subtly alters the tautomeric equilibrium of the PLP cofactor within the ...
Carolina Conter, Reyes Núñez‐Franco, Duaa Walid Al‐Sadeq, Carmen Fernández‐Rodríguez, Naroa Goikoetxea‐Usandizaga, Gheyath K. Nasrallah, Michail Nomikos, Maria Luz Martinez‐Chantar, Alessandra Astegno, Gonzalo Jiménez‐Osés, Luis Alfonso Martínez‐Cruz   +10 more
wiley   +1 more source

Correction: Can we project well-being? Towards integral well-being projections in climate models and beyond

Humanities & Social Sciences Communications
Kedi Liu, Ranran Wang, Inge Schrijver, Rutger Hoekstra   +3 more
doaj   +1 more source

The efficacy and safety of asciminib treatment in patients with chronic myeloid leukemia as a second-line or beyond second-line treatment: a systematic review and meta-analysis. [PDF]

Ther Adv Hematol
Fan Z, Xie J, Su P, Tai J, Feng W, Xu R, Ouyang Y.   +6 more
europepmc   +1 more source

How Trustworthy is Light Transmittance Platelet Aggregometry With Low Platelet Count Samples? Insights From Test Replicates and Retrospective Analysis of Several Decades of Diagnostic Samples

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Light transmission platelet aggregometry (LTA) is useful to diagnose platelet function disorders (PFD). We evaluated the precision and reproducibility of LTA with low platelet count platelet‐rich plasma (LPRP). Methods LPRP maximal aggregation (MA) precision for informative agonists and LTA reproducibility were assessed using ...
Catherine P. M. Hayward, Rabab Al Dawood, Lindsay Wice, Karen A. Moffat   +3 more
wiley   +1 more source

The Effects of Lutein-Containing Supplement Intake on Glycation Inhibition Among Diabetic Patients with Cataracts. [PDF]

Int J Mol Sci
Hayashi R, Hayashi S, Machida S.
europepmc   +1 more source

A CD4+ T CELL CLONE SELECTED FROM A CML PATIENT AFTER DONOR LYMPHOCYTE INFUSION RECOGNIZES BCR-ABL BREAKPOINT PEPTIDES BUT NOT TUMOR CELLS1

, 2001
Emmanuel Zorn, Enrica Orsini, Catherine J. Wu, Brady L. Stein, Antoinette Chillemi, Christine Canning, Edwin P. Alyea, Robert J. Soiffer, Jerome Ritz   +8 more
openalex   +1 more source

Discordant erythropoiesis in CML [PDF]

Leukemia, 1998
J. L. Lewis, Myrtle Y. Gordon, J. M. Goldman, S. B. Marley   +3 more
openaire   +2 more sources

Movement behaviours of stocked and wild lake trout Salvelinus namaycush determined using acoustic telemetry

Journal of Fish Biology, EarlyView.
Abstract Hatchery practices are a critical tool of fisheries management to supplement diminished fish populations and restore extirpated species. However, stocking programs that successfully restore self‐sustaining populations are rare. Unintentional artificial selection and domestication of hatchery‐reared fish are potential limitations to the success
Matthew H. Futia, J. Ellen Marsden
wiley   +1 more source

Global, regional, and national burden of congenital musculoskeletal and limb anomalies, 1990-2021: a systematic analysis of the global burden of disease in 2021. [PDF]

Trop Med Health
Luo Y, Zheng R, Chen J, Deng M, Zhang Z, Tan Z, Bai Z.   +6 more
europepmc   +1 more source