Results 351 to 360 of about 216,439 (378)
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Science Translational Medicine, 2017
Combining two BCR-ABL1 inhibitors with nonoverlapping mechanisms of action eradicates CML and prevents recurrence.
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Combining two BCR-ABL1 inhibitors with nonoverlapping mechanisms of action eradicates CML and prevents recurrence.
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Studies on the Specificity of CML Report from a CML‐Workshop
Tissue Antigens, 1978In a collaboratory study involving eight different laboratories 30 human, mixed lymphocyte culture educated cytotoxic/ymphocytes (CTLs) were identified yielding reproducible cytolysis on allogenic lymphocyte target cells without detectable HLA—A, B (and C) antigenic sharing between stimulator and target cells.These CTLs were collected in one laboratory
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CML: a model for targeted therapy
Best Practice & Research Clinical Haematology, 2009The discovery of the Philadelphia (Ph) chromosome represented the first step towards understanding the molecular basis of haematological malignancies. Subsequent developments including the characterisation of t(9;22)(q34;q11) translocation, the identification of the breakpoint cluster region as well as the demonstration that retrovirally mediated ...
CILLONI, Daniela, SAGLIO, Giuseppe
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CML in pregnancy and childhood
Best Practice & Research Clinical Haematology, 2009With the improved survivals offered by the tyrosine kinase inhibitors has come the necessity to address issues relating to quality of life and one such area is that of fertility and parenting. Animal data suggest that imatinib at standard dosages is unlikely to impair fertility in either adult males or females but human data remain limited.
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Investigação e Intervenção em Recursos Humanos, 2014
As ideias, boas, ou más, nascem das pessoas e quanto mais pessoas se debruçarem sobre um problema, maior será a probabilidade de que uma boa solução para o mesmo seja encontrada. As novas medidas de consolidação orçamental preconizadas pelo Orçamento de Estado de 2011, vieram reduzir os salários na Administração Pública, vedar a adoção dos mecanismos ...
Margarida Felgueiras +4 more
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As ideias, boas, ou más, nascem das pessoas e quanto mais pessoas se debruçarem sobre um problema, maior será a probabilidade de que uma boa solução para o mesmo seja encontrada. As novas medidas de consolidação orçamental preconizadas pelo Orçamento de Estado de 2011, vieram reduzir os salários na Administração Pública, vedar a adoção dos mecanismos ...
Margarida Felgueiras +4 more
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International Congress Series, 2002
Abstract This article summarizes the history of N e -(carboxymethyl)lysine (CML), from its discovery as a product of cleavage of Amadori adducts on proteins, to its recognition as the major Maillard reaction product in tissue proteins, and its role as an indicator of glycoxidative, lipoxidative, oxidative and carbonyl stress in biological systems ...
Suzanne R. Thorpe, John W. Baynes
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Abstract This article summarizes the history of N e -(carboxymethyl)lysine (CML), from its discovery as a product of cleavage of Amadori adducts on proteins, to its recognition as the major Maillard reaction product in tissue proteins, and its role as an indicator of glycoxidative, lipoxidative, oxidative and carbonyl stress in biological systems ...
Suzanne R. Thorpe, John W. Baynes
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Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice.
Molecular Nutrition & Food Research, 2015SCOPE Advanced glycation end-products (AGEs) are endogenously produced and are present in food. N(ε)-carboxymethyllysine (CML) is an endothelial activator via the receptor for AGEs (RAGEs) and is a major dietary AGE. This work investigated the effects of
N. Grossin +10 more
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The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
Nature Reviews. Cancer, 2020D. Vetrie, G. Helgason, M. Copland
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Current Treatment Concepts of CML
Current Cancer Drug Targets, 2011The elucidation of the triggering molecular mechanism of chronic myeloid leukemia gave rise to the development of imatinib, a tyrosine kinase inhibitor and a prototype of target-oriented drugs. Imatinib led to impressing response and survival rates and now represents the standard therapy of CML.
Armin Leitner +2 more
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No more transplantation in CML?
Blood, 2007Allogeneic stem cell transplantation has been considered the only curative therapy for chronic myeloid leukemia (CML). However, since 1999 the number of transplantations reported to scientific groups has substantially dropped.
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