The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen +8 more
wiley +1 more source
FuTCM-PDD: a multi-level information fusion framework integrating KAN modeling and AutoML for phenotype-based drug discovery from Traditional Chinese Medicine. [PDF]
Wang Z +10 more
europepmc +1 more source
pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang +11 more
wiley +1 more source
Modern confined masonry (CM) construction consists of masonry walls confined by reinforced concrete (RC) tie‐columns and tie‐beams. When built correctly, CM buildings have shown good performance in earthquake's shaking. Even though CM construction has been practised for almost a century in some Latin American countries, its use and standardisation are ...
Ahsana Parammal Vatteri +23 more
wiley +1 more source
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity. [PDF]
Zhang M +8 more
europepmc +1 more source
Abstract This pilot study evaluated a personalized sleep intervention incorporating motivational interviewing techniques to address sleep barriers, along with tailored sleep hygiene and extension for chronic short sleepers. Eleven university students completed a 14‐day sequential intervention (baseline, sleep hygiene and a combined phase adding 90‐min ...
Wei Wang +11 more
wiley +1 more source
Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz +23 more
wiley +1 more source
Integrated Transcriptomic and Metabolomic Analyses Reveal Acyl-CoA Dehydrogenase-Mediated Primordium Formation and Metabolite Synthesis in <i>Cordyceps militaris</i>. [PDF]
Zhou X, Xue L, Luo Y, Tong X, Guo J.
europepmc +1 more source
Fusarium triseptatum, F. kalimantanense, and Fusarium inflexum Clade, all members of the Fusarium oxysporum species complex FOSC, together with F. udum, a member of the Fusarium fujikuroi species complex FFSC, are reported for the first time as aetiological agents of Fusarium wilt of Passiflora.
Janaina M. Sousa +6 more
wiley +1 more source
The interconnections between novel adiposity indices and cardiometabolic multimorbidity in Chinese adults: a population-based cross-sectional study. [PDF]
Guo Z, Dong M, Liang J, Wang L, Deng S.
europepmc +1 more source

