Results 101 to 110 of about 200,140 (301)

Tunable Applicator for Microneedle‐Based Medical Devices

open access: yesAdvanced Materials Technologies, EarlyView.
This paper presents a simple, low‐cost tunable applicator (TAPP) for microneedle array patches that uses a material‐agnostic controlled‐fracture mechanism to ensure reliable skin penetration and uniform array engagement. The scalable, modular design is compatible with injection molding and 3D printing, can be integrated directly into patches, and is ...
Dan Ilyn   +9 more
wiley   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

open access: yesAdvanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto   +6 more
wiley   +1 more source

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

open access: yesNeurobiology of Disease, 2018
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A2A receptors (A2AR) are mostly located in synapses controlling synaptic plasticity.
António C. Silva   +9 more
doaj   +1 more source

Broadband Directional Thermal Radiation with Asymmetric Femtosecond Laser‐Processed Surfaces

open access: yesAdvanced Optical Materials, EarlyView.
Femtosecond laser processing is used to scalably create self‐organized angled microstructures which exhibit highly directional emissivity that occurs for all polarizations. Laser parameters are tuned to alter the surface features, control the direction of emission, and enhance the directional emissivity. Electromagnetic modeling is performed to analyze
Andrew Butler   +8 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

open access: yesHepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso   +16 more
wiley   +1 more source

Collision‐Resilient Winged Drones Enabled by Tensegrity Structures

open access: yesAdvanced Robotics Research, EarlyView.
Based on structures of birds such as the woodpeck, this article presents the collision‐resilient aerial robot, SWIFT. SWIFT leverages tensegrity structures in the fuselage and wings which allow it to undergo large deformations in a crash, without sustaining damage. Experiments show that SWIFT can reduce impact forces by 70% over conventional structures.
Omar Aloui   +5 more
wiley   +1 more source

UTact: Underwater Vision‐Based Tactile Sensor with Geometry Reconstruction and Contact Force Estimation

open access: yesAdvanced Robotics Research, EarlyView.
Embedded flexible sensing technologies advance underwater soft robotics, yet most systems still suffer from hysteresis and limited perceptiveness. Instead, vision‐based tactile sensors provide reliable and rapid feedback essential for complex underwater tasks.
Qiyi Zhang   +5 more
wiley   +1 more source

TacScope: A Miniaturized Vision‐Based Tactile Sensor for Surgical Applications

open access: yesAdvanced Robotics Research, EarlyView.
TacScope is a compact, vision‐based tactile sensor designed for robot‐assisted surgery. By leveraging a curved elastomer surface with pressure‐sensitive particle redistribution, it captures high‐resolution 3D tactile feedback. TacScope enables accurate tumor detection and shape classification beneath soft tissue phantoms, offering a scalable, low‐cost ...
Md Rakibul Islam Prince   +3 more
wiley   +1 more source

The interstellar gas-phase chemistry of HCN and HNC

open access: yes, 2014
We review the reactions involving HCN and HNC in dark molecular clouds to elucidate new chemical sources and sinks of these isomers. We find that the most important reactions for the HCN-HNC system are Dissociative Recombination (DR) reactions of HCNH ...
Hickson, Kevin M.   +2 more
core   +3 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

open access: yesAdvanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li   +9 more
wiley   +1 more source

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