Results 61 to 70 of about 197,689 (281)

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Journal of Neuroinflammation, 2020
Background After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known etiology.
Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso   +8 more
doaj   +1 more source

Superhumps and Repetitive Rebrightenings of the WZ Sge-Type Dwarf Nova, EG Cancri

, 2003
We report on time-resolved photometric observations of the WZ Sge-type dwarf nova, EG Cnc (Huruhata's variable, see also http://www.kusastro.kyoto-u.ac.jp/vsnet/DNe/egcnc.html), during its superoutburst in 1996-1997.
Baba, Hajime, Kato, Taichi, Matsumoto, Katsura, Nogami, Daisaku, 加藤, 太一, 松本, 桂, 野上, 大作, 馬場, 肇   +7 more
core   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Nature Communications, 2022
Spatial control of gene expression is critical to modulate cellular functions and deconstruct the function of individual genes in biological processes.
Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho, Lino Ferreira   +9 more
doaj   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

Dimensional Control of Aircraft Transmission Bodies Using CNC Machines and Neuro-Fuzzy Systems

Applied Sciences, 2019
The article deals with the selected aspects of quality control of aircraft accessory drive train bodies. The work presents the concept of control of selected dimensional and shape characteristics.
Grzegorz Bomba, Piotr Gierlak
doaj   +1 more source

Adenosine A2A receptors control generalization of contextual fear in rats

Translational Psychiatry, 2023
Fear learning is essential to survival, but traumatic events may lead to abnormal fear consolidation and overgeneralization, triggering fear responses in safe environments, as occurs in post-traumatic stress disorder (PTSD). Adenosine A2A receptors (A2AR)
Ana P. Simões, Marina A. M. Portes, Cátia R. Lopes, Felipe Vanz, Vanessa S. Lourenço, Anna Pliássova, Ingride L. Gaspar, Henrique B. Silva, Ângelo R. Tomé, Paula M. Canas, Rui D. Prediger, Rodrigo A. Cunha   +11 more
doaj   +1 more source

Development of a Novel MultiBody Mechatronic Model for Five-Axis CNC Machine Tool [PDF]

, 2015
The paper presents the development of a mechatronic hybrid model for Geiss five-axis CNC machine tool using MultiBody-System (MBS) approach. The motion control systems comprising electrical and mechanical elements are analyzed and modeled.
Papananias, M., Pislaru, Crinela, Sztendel, S.   +2 more
core  

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

PENGEMBANGAN MODUL PENGGUNAAN MASTERCAM SEBAGAI MEDIA SIMULATOR PADA MATA PELAJARAN MEMPROGRAM MESIN NC/CNC DI SMK NEGERI 2 KLATEN [PDF]

, 2012
Penelitian ini bertujuan untuk mengembangkan media pembelajaran dalam bentuk prototype modul penggunaan Mastercam sebagai media simulator pada mata pelajaran memprogram mesin NC/CNC, untuk meningkatkan keterampilan belajar siswa di SMK Negeri 2 Klaten ...
Dangu Bagus , Sanjaya
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