Results 11 to 20 of about 41,489 (223)

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels. [PDF]

Adv Sci (Weinh)
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Liu H, Benndorf K, Aldakul YK, Sun H.
europepmc   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Structural studies of CNG repeats [PDF]

Nucleic Acids Research, 2014
CNG repeats (where N denotes one of the four natural nucleotides) are abundant in the human genome. Their tendency to undergo expansion can lead to hereditary diseases known as TREDs (trinucleotide repeat expansion disorders). The toxic factor can be protein, if the abnormal gene is expressed, or the gene transcript, or both.
Kiliszek, Agnieszka, Rypniewski, Wojciech   +1 more
openaire   +2 more sources

Sterile neutrinos at the CNGS [PDF]

Journal of High Energy Physics, 2007
We study the potential of the CNGS beam in constraining the parameter space of a model with one sterile neutrino separated from three active ones by an O(eV^2) mass-squared difference, Δm^2_SBL. We perform our analysis using the OPERA detector as a reference (our analysis can be upgraded including a detailed simulation of the ICARUS detector). We point
Donini, A, Maltoni, M, Meloni, D, Migliozzi, P, TERRANOVA, FRANCESCO   +4 more
openaire   +3 more sources

The hot pick-up technique for batch assembly of van der Waals heterostructures

Nature Communications, 2016
The reliable assembly of two-dimensional materials into van der Waals heterostructures is a critical step towards nanoscale electronic integration. Here the authors present a technique for batch fabrication of graphene/boron nitride stacks with clean ...
Filippo Pizzocchero, Lene Gammelgaard, Bjarke S. Jessen, José M. Caridad, Lei Wang, James Hone, Peter Bøggild, Timothy J. Booth   +7 more
doaj   +1 more source

Conversion of Gasoline Vehicles to CNG Hybrid Vehicles (CNG-Electric Vehicles) [PDF]

Research Journal of Applied Sciences, Engineering and Technology, 2013
The aim of this study is investigation of the feasibility and advantages of using the natural gas as an alternative to gasoline as a fuel for hybrid electric vehicles. Operating CNG vehicles are really beneficial in the Middle East region considering the fact that gasoline is offered at a heavily subsidized price and therefore, by converting a ...
Hassan Moghbelli, Abolfazl Halvaei Niasar   +1 more
openaire   +1 more source

Conductance quantization suppression in the quantum Hall regime

Nature Communications, 2018
Conductance quantization is the hallmark of non-interacting confined systems. The authors show that the quantization in graphene nanoconstrictions with low edge disorder is suppressed in the quantum Hall regime.
José M. Caridad, Stephen R. Power, Mikkel R. Lotz, Artsem A. Shylau, Joachim D. Thomsen, Lene Gammelgaard, Timothy J. Booth, Antti-Pekka Jauho, Peter Bøggild   +8 more
doaj   +1 more source

An Experimental Study on the Performance and Emission of the diesel/CNG Dual-Fuel Combustion Mode in a Stationary CI Engine

Energies, 2019
One of the possibilities to reduce diesel fuel consumption and at the same time reduce the emission of diesel engines, is the use of alternative gaseous fuels, so far most commonly used to power spark ignition engines.
Arkadiusz Jamrozik, Wojciech Tutak, Karol Grab-Rogaliński   +2 more
doaj   +1 more source

Voltage Sensing in CNG Channels [PDF]

Biophysical Journal, 2011
Gating of cyclic nucleotide gated (CNG) channels is thought not to be voltage dependent. However, in the presence of symmetrical Rb+ and Cs+ CNGA1 channels exhibit a clear voltage and time dependent gating of macroscopic current. In symmetrical Rb+ and Cs+ the single channel conductance (γsc) and the open probability (Pop) of w.t.
Marchesi A, Mazzolini, Monica, Torre, Vincent   +2 more
openaire   +1 more source

cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function

Pharmaceutics, 2022
The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG) channel ...
Sophie Wucherpfennig, Wadood Haq, Valerie Popp, Sandeep Kesh, Soumyaparna Das, Christian Melle, Andreas Rentsch, Frank Schwede, François Paquet-Durand, Vasilica Nache   +9 more
doaj   +1 more source