Results 241 to 250 of about 608,970 (315)

Acupuncture as a potential host-directed therapeutic strategy in neuroinfectious diseases: a neuroimmune mechanistic perspective. [PDF]

Front Med (Lausanne)
Kim YJ.
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Breakthroughs and challenges of CAR-T cell therapy in treating hematologic malignancies of the central nervous system. [PDF]

Blood Sci
Li X, Da H, Zhao J, Yan Y, Wei J, Tian W.   +5 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Development of the Gutti Score: A Universal Clinical Assessment Framework for Patients Receiving Gabapentinoids, Opioids, Benzodiazepines, and Other Central Nervous System Depressants. [PDF]

Cureus
Gutti S, Riyadh S.
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Age, patient experience and satisfaction with breast cancer care: a cohort study using linked national cancer patient experience survey and cancer registry data. [PDF]

BMJ Open
Blacker S, Withrow DR, Boyle JM, Wang L, Delon C, Medina J, Horgan K, Dodwell D, Verrill M, Lemanska A, Frampton AE, Cromwell DA.   +11 more
europepmc   +1 more source

System Identification of Robotic Fish Swimming Reveals Roles of Reactive and Resistive Fluid Force in Two Distinct Swimming Gaits

Advanced Intelligent Systems, EarlyView.
System identification and particle image velocimetry reveal how a modular robotic fish changes thrust physics across gaits. A traveling‐wave, fish‐like motion draws thrust from resistive drag, while a resonant standing‐wave motion is driven by reactive pressure.
Donghao Li, Hankun Deng, Kundan Panta, Azar Panah, Bo Cheng   +4 more
wiley   +1 more source

CRLF2 rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: a possible link? [PDF]

Blood Adv
Gava F, Yates B, Sun Z, Li G, O'Koren C, Adhikari B, Lugar S, Shalabi H, Mattison R, Turkbey EB, Yuan CM, Paietta E, Wang HW, Mullighan C, Silbert SK, Litzow M, Shah NN.   +16 more
europepmc   +1 more source