Results 91 to 100 of about 5,218,116 (247)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Co-occurrence analysis using VOSViewer of terms in GINA. [PDF]

Co-occurrence analysis using VOSViewer of terms in GINA.
Huei-Chia Hsueh (17879735), Chih-Wei Huang (572370), Shuo-Chen Chien (7836836), Hsuan-Chia Yang (7836830), Usman Iqbal (492423), Li-Fong Lin (4710116), Wen-Shan Jian (306772)   +6 more
core   +1 more source

Global Co‐Occurrence Patterns of Ischemic Heart Disease and Metabolic Dysfunction–Associated Steatotic Liver Disease: Spatial Clusters, Risk Factors, and Quality‐of‐Care Index

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ischemic heart disease and metabolic dysfunction–associated steatotic liver disease represent significant global health challenges, characterized by overlapping pathophysiological mechanisms.
Wei Wang, Wei‐dong Jiang, Lin Wang, Jin‐hui Sun, Zi‐jia Li, Ze‐zhong Wu, Ai‐qiong Qin, Shi Qiu, Wen Liu   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Introduction to deep learning methods for multi‐species predictions

Methods in Ecology and Evolution
Predicting species distributions and entire communities is crucial for ecologists, to enhance our understanding of the drivers behind species distributions and community assembly and to provide quantitative data for conservation efforts.
Yuqing Hu, Sara Si‐Moussi, Wilfried Thuiller   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Coexistence of Sympatric Large Carnivores: Spatio‐Temporal Interactions Between Tigers and Leopards in Parsa National Park, Nepal

Ecology and Evolution
Understanding interspecific interactions between tigers (Panthera tigris) and leopards (Panthera pardus) is crucial for effective conservation planning. However, most studies have been conducted only in well‐known protected areas, leaving knowledge gaps ...
Dol Raj Thanet, Pramod Raj Regmi, Babu Ram Lamichhane, Dipanjan Naha, Caitlin Kupferman, James C. Beasley, Mandip Pangeni, Anil Shrestha, Saneer Lamichhane, Haribhadra Acharya, Bed Kumar Dhakal, Bhagawan Raj Dahal, Chiranjibi Prasad Pokheral, Naresh Subedi   +13 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Concurrent Treatment With Lorlatinib and Dinutuximab Beta Induced Acute Gastric Dilation in a Pediatric Patient With Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
Suna Lin, Linjie Li, JiJun Chen, Zhaokun Tao, Lifeng Zhang, Junqing Mao, Jinhu Wang   +6 more
wiley   +1 more source