Results 61 to 70 of about 11,891,244 (218)
Circular on Registration and Management of Public Service Retirement Benefit Schemes [PDF]
On 24th November 2010, the National Treasury issued Treasury Circular No. 18/2010 to guide the registration and management of public service retirement benefits schemes and ensure equity in sharing the cost of funding scheme benefits between the employer
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Central Co-Op Benefit poster, October 26, 1986
, 1986 The poster seen here advertises a benefit concert for a planned expansion of the Central Co-op, a market on Seattle's Capitol Hill at 12th Avenue and East Denny Way. The event featured performances by Rumors of the Big Wave, the Mazeltones, Doug Benecke,
Central Co-op
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Circular on guidelines for the Preparation of FY 2024/2025 and the Medium-Term Budget
, 2023 In accordance with the provisions of Article 220 of the Constitution and Sections 35(e) and 36 of the Public Finance Management Act, 2012, the budgetmaking process for a given financial year is expected to commence not later than 30th August of the ...
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Inverse software configuration management [PDF]
, 1998 Software systems are playing an increasingly important role in almost every aspect of today’s society such that they impact on our businesses, industry, leisure, health and safety. Many of these systems are extremely large and complex and depend upon the
McCrindle, Rachel Jane
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source