Results 121 to 130 of about 15,782,143 (303)

Research on the collaborative mechanism between site selection optimization model and control of green space planning under the background of urban renewal

Discover Sustainability
As a part of integrated urban ecosystems, green space is an important target of urban renewal planning. In the process of urban renewal of green space, it is difficult to control the special planning for green space systems, and the scale of urban public
Xiangyun Li, Desheng Dai, Jingwen Dong, Kaili Hu   +3 more
doaj   +1 more source

Structural design and analysis of connected structure in Chengdu Financial Innovation Center Phase 1

Jianzhu Jiegou
The project of Chengdu Financial Innovation Center Phase 1 consists of five high-rise towers，large-chassis podiums and large-span sky-bridge to form an enclosed building cluster. Among them，the T1 tower adopts steel frame structure，the T2～T5 towers adopt
ZHU Jing, LIU Wei, WANG Wu, ZHU Guo, LUO Aolei, SHU Yuan   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spanning capacity analysis of self-anchored suspension bridges based on the stability and compression strength of stiffening girder

Journal of Asian Architecture and Building Engineering
Considerable axial compression stress exists in the stiffening girder of self-anchored suspension bridges. Therefore, failures of self-anchored suspension bridges will be either due to material failure or instability of the stiffening girder, which will ...
Cunyu Cui, Changyan Niu, Jianguo Dai, Yongcheng Lu   +3 more
doaj   +1 more source

Application of direct analysis method in lightweight spatial steel structures

Jianzhu Jiegou
In order to evaluating the applicability and advantages of the direct analysis method for lightweight spatial steel structures，a lightweight spatial steel structure formed by a single-layer diagonal grid was taken as the research object to compare the ...
WANG Pengfei, WANG Wu, FU Anjun, XIE Kai, SONG Fuping, CAI Xunhua   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Bio/CMOS interfaces and co-design

This textbook demonstrates new paradigms for the interface between CMOS circuits and the biological world. A deep theoretical description of such an interface is defined and discussed, while various real applications are demonstrated by also discussing ...
Carrara, Sandro
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Research on optimization method of viscous dampers based on optimal additional damping ratio

Jianzhu Jiegou
To reveal the influence law of viscous damper parameters on the supplemental damping ratio and realize the cost-effective seismic mitigation design，the optimization method of damping coefficients and damping exponents was investigated.
WANG Pengfei, FU Anjun, XIE Kai, SONG Fuping, CAI Xunhua, LIU Zhen   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source