Results 161 to 170 of about 789,707 (313)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cardiac Output During Exercise: Thermodilution Versus Direct Fick. [PDF]

J Am Heart Assoc
Siuba MT, Lane J, Mendpara V, Toth D, Paul D, Xiao H, Wang X, Tonelli AR.   +7 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Biochemical and Pharmacological Studies on Kynurenic Acid Metabolism in the <i>Helix pomatia</i>-Snail Model of Learning and Memory. [PDF]

Biomolecules
Baran H, Kronsteiner C.
europepmc   +1 more source

A Squandered Opportunity: Even after the Financial Crisis, Top Positions in Large Financial Firms Still Largely Occupied by Men [PDF]

Despite the recent financial crisis and widespread mergers in the banking industry, the German financial sector remains largely unchanged in one respect: the percentage of women on the corporate boards of Germany's banks and insurance companies was ...
Elke Holst, Julia Schimeta
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fingerprint evidence in exoneration cases. [PDF]

Forensic Sci Int Synerg
Cole SA, Schamp M.
europepmc   +1 more source

Governance of stakeholder relationships: The German and Dutch experience [PDF]

Countries' governance institutions to a varying degree support stakeholders to invest in relationship-specific assets. The function of governance institutions is to strengthen the commitment of parties to keep to an initial agreement. Thus, international
Corina den Broeder, Franco Bruni, George Gelauff   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Y-Co metal-organic framework for sensitive electrochemical determination of doxorubicin hydrochloride. [PDF]

ADMET DMPK
Mir S, Torbati NA, Amani V, Tajik S, Beitollahi H.   +4 more
europepmc   +1 more source