Results 111 to 120 of about 603,240 (292)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of Shouhui Tongbian capsule against diphenoxylate-induced slow transit constipation in rats

Chinese Medicine
Background Slow transit constipation (STC) is highly prevalent and has rising incidence. Shouhui Tongbian capsule (SHTB) is a traditional Chinese Medicine formula with extensive and highly efficacious usage in STC treatment, however, its mechanism of ...
Jiaying Yang, He Xiao, Jingchun Yao, Pin Zhang, Bojiao Yi, Zhengyu Fang, Na Guo, Yongxia Guan, Guimin Zhang   +8 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

ACDD: Multi-traffic Participant Interactive Motion Prediction with Agent -Centric Scene Modeling and Dual-Layer Decoding

International Journal of Computational Intelligence Systems
Interactive trajectory prediction plays an indispensable role in autonomous driving systems, acting as a key link between perception and decision-making. In complex urban environments, the dynamic interactions among heterogeneous traffic participants and
Ke Liu, Honglin Wang, Siju Chen, Yao Fu, Yulong Lei, Yuhai Wang   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Generalized (co)integrals on coideal subalgebras

, 2018
Given a a Hopf algebra $H$, its left coideal subalgebra $A$ and a non-zero multiplicative functional $ $ on $A$, we define the space of left $ $-integrals $L^A_ \subset A$. We observe that $\dim L^A_ =1$ if $A$ is a Frobenius algebra and we conclude this equality for finite dimensional left coideal subalgebras of a weakly finite Hopf algebra.
openaire   +2 more sources

Financial Innovation and Stability of Money Demand Function in Post–reform period in India [PDF]

Innovation in financial sector, financial reforms and changes in the policy environment are the factors responsible for instability in the money demanded in an economy.
Manoj Kumar Pandey, Prakash Singh
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Exchange Rates and Trade Balance: The Case of Iran [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2007
This paper studies the impact of Rial's real devaluation and scale  variables (domestic and foreign real income) on Iran's trade balance using the Johansen-Juselius and ARDL methods for the period 1338-1383 (1960-2004).
Mohsen Mehrara, Alireza Abdi
doaj  

Co-integration Between Globalisation and Economic Growth

Finance and Market, 2017
<span class="fontstyle0">This paper analyses the co-integration relationship between globalisation and economic<br />growth of 27 more or less developed countries across almost all Continents for the time period<br />1970–2013. Globalisation is </span><span class="fontstyle2">proxied </span><span class="fontstyle0"
openaire   +1 more source