Results 41 to 50 of about 8,292,072 (268)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of the Influence of Different Turbulence Models on the Prediction of Vehicle Aerodynamic Performance

Energies
As global energy grows short and environmental governance pressure increases, the automotive industry, a major energy consumer and pollution emitter, must enhance vehicle aerodynamics to cut energy use and emissions. This study creates an open-domain and
Luwei Wang, Xingjun Hu, Peng Guo, Zirui Wang, Jingyu Wang, Yuqi Wang, Yan Ma, Ying Li, Jing Zhao, Xu Yang, Ruixing Ma, Yinan Zhu, Jianjiao Deng   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An easy α-glycosylation methodology for the synthesis and stereochemistry of mycoplasma α-glycolipid antigens

Beilstein Journal of Organic Chemistry, 2012
Mycoplasma fermentans possesses unique α-glycolipid antigens (GGPL-I and GGPL-III) at the cytoplasm membrane, which carry a phosphocholine group at the sugar primary (6-OH) position.
Yoshihiro Nishida, Yuko Shingu, Yuan Mengfei, Kazuo Fukuda, Hirofumi Dohi, Sachie Matsuda, Kazuhiro Matsuda   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigation of the Efficacy and Mechanism of Monoacylglycerol Lipase Inhibitors in Diabetic Foot Ulcers

Pharmaceuticals
Background/Objectives: Wound healing proceeds in a timely and sequential manner through four well-defined phases: hemostasis, inflammation, proliferation, and remodeling.
Zixia Liang, Ying Wang, Meijia Li, Honghua Li, Yanzhong Han, Yun Zhao, Jian Yang, Yujun Tan, Guoxin Dai, Na Guo, Jingchun Yao, Xiaoyan Lu, Guimin Zhang   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway

Journal of Neuroinflammation
In recent years, the gut microbiota has been increasingly recognized for its influence on various central nervous system diseases mediated by microglia, yet the underlying mechanisms remain unclear.
Qingyu Cao, Mengmeng Shen, Ruoqiu Li, Yan Liu, Zhen Zeng, Jidong Zhou, Dejun Niu, Quancai Zhang, Rongrong Wang, Jingchun Yao, Guimin Zhang   +10 more
doaj   +1 more source

Variable Impedance Control for Active Suspension of Off-Road Vehicles on Deformable Terrain Considering Soil Sinkage

Vibration
Off-road vehicle control designs often neglect the complex tire–soil interactions inherent to soft terrain. This paper proposes a Variable Impedance Control (VIC) strategy integrated with a high-fidelity terramechanics model.
Jiaqi Zhao, Mingxin Liu, Xulong Jin, Youlong Du, Ye Zhuang   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source