ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Brazilian Journal of BiologyThe broadband anchovy (Anchoviella lepidentostole) is one of the most important fishery resources for economic and social development of Iguape City and for the whole of the south coast of São Paulo state.
JT. Mendonça, RP. Sobrinho
doaj +1 more source
Factors promoting hunting groups' sustainable harvest of moose in a co-management system. [PDF]
Sci Rep, 2023 Tuominen LS +8 more
europepmc +1 more source
Management Accounting Practices in Nepalese Co-operative Organizations
, 2021 Mukti Prasad Neupane
openalex +2 more sources
Regional Workshop on Co-management in Small-Scale Fisheries: Lessons Learned and Best Practices 12-13 December 2012, Bangkok, Thailand [PDF]
, 2012 An FAO project, the Regional Fisheries Livelihoods Programme, which is funded by Spain, has worked with the Timorese authorities and coastal communities to build local capacity and put in place effective methods to gather a variety of important fisheries
Crispen Wilson +5 more
core
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Towards the Business Federation in Top Management Consulting in Europe: The Role of Co-creation
, 2012 Carsten Martin Syvertsen
openalex +2 more sources
The Impacts of Co-Management Towards Sustainable Development and Utilization of Fisheries Resources in Lake Naivasha, Kenya [PDF]
, 2020 Edna Waithaka +8 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source