Results 131 to 140 of about 6,829,809 (314)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Summarizing relationships between chemicals, genes, proteins, and diseases in PubChem using analysis of their co-occurrences in patents

Journal of Cheminformatics
The knowledge panels in PubChem allow users to quickly identify and summarize important relationships between chemicals, genes, proteins, and diseases by analyzing the co-occurrences of those entities in a collection of text documents.
Leonid Zaslavsky, Tiejun Cheng, Asta Gindulyte, Sunghwan Kim, Paul A. Thiessen, Evan E. Bolton   +5 more
doaj   +1 more source

Co-occurrence of chronic pain, major depressive disorder and/or angina in GS:SFHS overall.

, 2017
Co-occurrence of chronic pain, major depressive disorder and/or angina in GS:SFHS overall.
Blair H. Smith (625812), Lynne J. Hocking (120822), Andrea V. Burri (298832), Oliver van Hecke (3772381), Archie Campbell (669891), Sandosh Padmanabhan (238533), David J. Porteous (107720), Haruka Tanaka (3772378), Frances M. K. Williams (108925), Nicola Torrance (64308), Andrew M. McIntosh (292147)   +10 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Simultaneous pollinator occurence (Hymenoptera, Agaoninae) in a threatened species: Ficus mexiae Standley (Moraceae)

Brazilian Journal of Biology
In Brazil, Ficus mexiae is classified as Vulnerable under IUCN criteria, and to date there is only one report on pollinator activity for this species.
. Schiffler, Kloss TG. G., JR Matos
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A case of Nelson’s syndrome with adrenal crisis occurring 21 years post-adrenalectomy for Cushing’s disease

BMC Endocrine Disorders
Background Nelson’s syndrome is a known complication of bilateral adrenalectomy for Cushing’s disease, and lifelong glucocorticoid replacement is essential in these patients to prevent adrenal insufficiency, a condition that can culminate in life ...
Mengmeng Wang, Yan Xu, Ziyang Dong, Yanli Song   +3 more
doaj   +1 more source

Co-occurrence of Spodoptera frugiperda and Busseola fusca on maize plants.

, 2019
Co-occurrence of Spodoptera frugiperda and Busseola fusca on maize plants.
Rachid Hanna (6645758), Komi Kouma Mokpokpo Fiaboe (6645779), Cargele Masso (6645773), Sergine Ngatat (6645770), Maurice Tindo (182316), Albert Fomumbod Abang (6645764), Samuel Nanga Nanga (6645767), Rose Ndemah (3319032), Apollin Fotso Kuate (6645755), Armand R. P. Doumtsop Fotio (6645761), Christopher Suh (6645776)   +10 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source