Results 141 to 150 of about 3,752,368 (307)

When a business isn’t a business: law and the political in the history of the United Kingdom’s co-operative movement

open access: yesOñati Socio-Legal Series, 2011
Contemporary efforts to develop and promote co-operatives and the social economy confront a tension in the competing and often conflicting aims to achieve commercial sustainability in a capitalist market while also promoting social transformation ...
Tara Mulqueen
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Is the Ownership Structure Model a Decisive Determinant of Co-Operatives' Financial Success? A Financial Assessment

open access: yes
In this paper, the financial/ownership structures of agribusiness co-operatives (co-ops) are analyzed in order to examine whether new co-op models perform better than the more traditional ones. The assessment procedure introduces a new financial decision-
Pennings, Joost M.E.   +3 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

“Co-operative identityâ€: A theoretical concept for economic analysis of practical co-operation dynamics

open access: yes
Farmers’ problems and co-ordination of agricultural activities cannot be solved simply by EU and/or government support, or by private market co-ordination institutions.
Szabo, Gabor G.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Seeds of change: cultivating feminist leadership in the co-operatives of the MENA region

open access: yes
This paper examines women’s leadership in local group governance in Morocco, Tunisia, and Lebanon, highlighting rural co-operatives as key spaces for socioeconomic participation and agency.
Amil, Rola   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Farmers’ Satisfaction and Intention to Continue as Members of Agricultural Marketing Co-operatives: A Test of the Neoclassical and Transaction Costs Theories

open access: yes
Agricultural marketing co-operatives are one among a myriad of options that farmers have to market their products, making survival of the co-operative formula to depend on its capability to compete for the farmers’ satisfaction and membership.
Tantius, Peter H.   +2 more
core  

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