Results 141 to 150 of about 9,488,585 (304)

Karte der Ansiedelungen am Hafen von Apia, Insel Upolo [cartographic material] /

, 1879
Plate 3 from: [Maps of Oceania by L.Friederichsen & Co., probably published in Mitteilungen der Geographischen Gesellschaft in Hamburg, 1879]. Hamburg : L. Friederichsen & Co., 1879.; Map of Apia, Samoa.
L. Friederichsen & Co.
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Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Queensland [cartographic material]

Map of Queensland showing administrative districts highlighted in different colours; Plate [5] from: Whitehead's Atlas of Australasia. Melbourne : Published by E. Whitehead & Co., 1870.; Also available in an electronic version via the internet at: http:/
Whitehead & Co.
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Public services management and co-production: a necessity, a fashion or a new public service ethos?

, 2013
This paper aims at investigating the drivers of user/citizen involvement in the public service provision, the formal and informal co-production structures, the roles played by public managers in order to support co-production.
RUFFINI, RENATO, SICILIA, MARIA FRANCESCA, GUARINI, ENRICO, A. Sancino, M. Andreani   +4 more
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Comparing the adoption of co-production in health and welfare contexts

, 2020
The healthcare sector is facing new challenges related to changes in demographic, epidemiology and lifestyle of the worldwide population. To optimize current healthcare services, it is important to identify solutions that support providers in ...
Cristina Masella, Raffaella Gualandi, Eleonora Gheduzzi   +2 more
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

South Australia [cartographic material]

Map of South Australia showing administrative districts highlighted in different colours; Plate [4] from: Whitehead's Atlas of Australasia. Melbourne : Published by E.
Whitehead & Co.
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F.E. Hiscocks & Co.'s map of Victorian [cartographic material] : being a reference map to their Victorian counties atlas, showing roads, distances, relative positions of counties &c, &c.

, 1874
Cadastral map of Victoria showing roads, railways and gold workings.; "Hamel & Ferguson."; Plate [22] from: F.E. Hiscocks & Co.'s new Victorian counties atlas, 1874. Melbourne : G.
F.E. Hiscocks & Co.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source