Results 171 to 180 of about 1,748,214 (284)

Redesigning mental health research systems from within: the role of peer-led co-production. [PDF]

Front Health Serv
D'souza NA, Rao S, Marchand K, Davies M, Dryburgh NSJ, Radomski AD, Aggarwal P, Mulligan C, Stringer JE, Austin A, Edwards J, Leach MD.   +11 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Co-production with marginalised workers: working with homecare workers and managers caring for people approaching end-of-life. [PDF]

Res Involv Engagem
Bayley Z, Forward C, Elliott-Button H, Krygier J, White C, Pearson M, Walker L, Moss C, Hussain J, Taylor P, Wray J, Roberts H, Johnson MJ.   +12 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Evolutionary game analysis of supply chain financing for film and television enterprises considering co-production. [PDF]

PLoS One
Zhen Y, Li H, Wang W.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Toward Predicting Interfacial Tension of Impure and Pure CO2‑Brine Systems Using Robust Correlative Approaches

ACS Omega
Chen Wei-yu, Lin Sun, Jiyong Zhou, Xuguang Li, Liping Huang, Guang Xia, Xiangli Meng, Kui Wang   +7 more
doaj   +1 more source

Learning from volcanic eruptions: Co-production of knowledge at Merapi and Kelud, Indonesia. [PDF]

Jamba
Solekhah N, Hakim FN, Wahyono E, Prayoga RA, Fatimah S, Purbandini L, Wibowo DP, Saparita R, Febriyandi Ys F, Humaedi MA.   +9 more
europepmc   +1 more source

Co-production of bio-ethanol, electricity and heat from biomass wastes: potential and R&D issues [PDF]

, 2001
Claassen, P.A.M., Elbersen, H.W., Jong, E.J., de, Laat, W.T.A.M., de, Niessen, J.J., Ree, R., van, Reith, J.H., Veenkamp, J.M.   +7 more
core   +1 more source