Results 171 to 180 of about 644,874 (261)

Correction: MS-ConTab: multi-scale contrastive learning of mutation signatures for Pan-Cancer representation and stratification. [PDF]

Bioinformatics
europepmc   +1 more source

A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3. [PDF]

Nat Plants
Jiménez-Sandoval P, Johanndrees O, Snoeck S, Harshith CY, Omary M, Broyart C, Rhodes J, Bender KW, Zipfel C, Santiago J.   +9 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Learning fuzzy representations for hypergraph node classification. [PDF]

Sci Rep
Sun Z, Geng R, Zhang G.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unsupervised adaptive sampling graph autoencoder for 3D surface encoding and mesh representation transfer. [PDF]

Med Image Anal
Cruz-Guerrero IA, Nagel J, Porras AR.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Correction: "There's no representation": a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians. [PDF]

Eur J Hum Genet
Nathan V, Akbar H, McInerney-Leo A, Gilroy D, Henders A, Naresh R, Choudhury N, Waqar M, Shah S, Yanes T, South Asian Genes and Health in Australia (SAGHA) research team.   +10 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Trends in Sex Representation in the American Society for Surgery of the Hand Committee and Annual Meeting Leadership from 2013 to 2024. [PDF]

J Hand Surg Glob Online
Diaz AR, Malta S, Sinclair MK, Dacus AR, Chhabra AB.   +4 more
europepmc   +1 more source