Results 71 to 80 of about 644,874 (261)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Social SciencesStudent-teacher relationships matter in creating inclusive student engagement opportunities in higher education. Student engagement is a wide-ranging topic, and much of the existing literature discusses student course representation (where student ...
Tanya Lubicz-Nawrocka, Xiuxiu Bao
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
To merge or not: The onto- and phylogenetic origin of co-representation
Co-representation during joint action is a hallmark of human cooperation, but its origin poses a puzzle: It apparently emerges late in ontogeny (around the age of four) suggesting it is cognitively demanding, but it has also been demonstrated in several nonhuman primate species.
Fabia Miss +3 more
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Learning Chinese Word Embeddings With Words and Subcharacter N-Grams
IEEE Access, 2019 Co-occurrence information between words is the basis of training word embeddings; besides, Chinese characters are composed of subcharacters, words made up by the same characters or subcharacters usually have similar semantics, but this internal ...
Ruizhi Kang +4 more
doaj +1 more source
Brain-to-brain synchrony during dyadic action co-representation under acute stress: evidence from fNIRS-based hyperscanning. [PDF]
Front Psychol, 2023 Lin S, Zhao H, Duan H.
europepmc +1 more source
Social moderators of action co-representation [PDF]
, 2013 Radboud Universiteit Nijmegen, 07 maart ...
openaire
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source