E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Vesicularity, bubble formation and noble gas fractionation during MORB degassing
, 2013 The objective of this study is to use molecular dynamics simulation (MD) to evaluate the vesicularity and noble gas fractionation, and to shed light on bubble formation during MORB degassing.
Aubry, G., Guillot, B., Sator, N.
core +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Effects of carbon dioxide addition on algae and treatment performance of high rate algal ponds : a thesis presented in partial fulfilment of the requirements of the degree of Master of Engineering in Environmental Engineering at Massey University [PDF]
, 2006 Waste stabilisation ponds have been used for treating a great variety of wastewaters around the world for many decades. More advanced systems combine anaerobic or advanced facultative ponds with high rate algal ponds (HRAP) followed by a number of algae ...
Heubeck, Stephan
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling
Nature CommunicationsCarbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs ubiquitous in pharmaceutically ...
Gabriel M. F. Batista +8 more
doaj +1 more source
Numerical investigation of air conditioning system configurations for achieving desired negative pressure in isolation rooms [PDF]
Engineering and Technology JournalThis paper investigates a novel study about the influence of airflow simulation of an air conditioner (AC) inlet angle impacting negative pressure control in an airborne isolation indoor room (AIIR).
Elaf Barrak +2 more
doaj +1 more source
Computational Study of CO2 Adsorption and Reduction on Doped Graphene Sheets [PDF]
, 2016 In recent decades, growing CO2 in the Earth\u27s atmosphere has become a major issue. Thus, it is crucial to reduce the level of concentration of CO2 in the atmosphere.
He, Haiying, Jagvaral, Yesukhei
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Bioenergetic trade-offs can reveal the path to superior microbial CO2 fixation pathways
mSystemsA comprehensive optimization of known prokaryotic autotrophic carbon dioxide (CO2) fixation pathways is presented that evaluates all their possible variants under different environmental conditions.
Ahmed Taha +2 more
doaj +1 more source