Results 161 to 170 of about 167,197 (305)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Protein folds and catalytic strategies at the origin of biological CO2 fixation. [PDF]

FEMS Microbiol Ecol
Mrnjavac N.
europepmc   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

A curated resource of chemolithoautotrophic genomes and marker genes for CO₂ fixation pathway prediction. [PDF]

Sci Data
Kawashima S, Okabeppu Y, Miyazawa S, Ichikawa N, Nagazumi H, Nishihara Y, Nakazato T, Goto S, Kurokawa K, Ishii M, Mori H.   +10 more
europepmc   +1 more source

Rhodopsin driven microbial CO₂ fixation using synthetic biology design. [PDF]

Environ Microbiol, 2023
Tu W, Huang WE.
europepmc   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Endowing plants with a dual-cycle heart to boost CO₂ fixation. [PDF]

Natl Sci Rev
Zhao C, Hao W, Chen X.
europepmc   +1 more source

A Proton-Coupled Electron Transfer Strategy to the Redox-Neutral Photocatalytic CO₂ Fixation. [PDF]

J Org Chem, 2023
Franceschi P, Rossin E, Goti G, Scopano A, Vega-Peñaloza A, Natali M, Singh D, Sartorel A, Dell'Amico L.   +8 more
europepmc   +1 more source

Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation

Advanced Materials, EarlyView.
LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines, Marcus Fletcher, Manuel Bibrowski, Karnyart Samnuan, Rongjun Chen, David J. Peeler, Amjad Abouselo, Morag R. Hunter, Molly M. Stevens, Nicholas J. Brooks, Yuval Elani   +10 more
wiley   +1 more source

Metabolic rewiring for enhanced itaconate yield through heterotrophic CO₂ fixation in Escherichia coli. [PDF]

J Biol Eng
Ye DY, Min M, Lim GY, Hwang HG, Jung GY, Lim HG.   +5 more
europepmc   +1 more source