Results 91 to 100 of about 2,898,513 (305)

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Largest Prospective Study of CO2 Laser Treatment in Hidradenitis Suppurativa Patients Showing Improved Quality of Life

JEADV Clinical Practice
Background Hidradenitis suppurativa (HS) can be a difficult disease to manage, especially in patients with prominent disease. CO2 laser can be used for the treatment of recurrent HS lesions with or without simultaneous systemic treatment. There is a lack
C. A. Daugaard, L. W. Schøsler, M. K. Rasmussen, L. Kibsgaard, A. Meszes, T. Høgsberg, T. Bertelsen   +6 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

Advanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel   +6 more
wiley   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Compact and full-range carbon dioxide sensor using photoacoustic and resonance dependent modes

Photoacoustics
A compact and robust optical excitation photoacoustic sensor with a self-integrated laser module excitation and an optimized differential resonator was developed to achieve high sensitivity and full linear range detection of carbon dioxide (CO2) based on
Yifan Li, Lixian Liu, Liang Zhao, Xueshi Zhang, Le Zhang, Jialiang Sun, Huiting Huan, Yize Liang, Jiyong Zhang, Xiaopeng Shao, Andreas Mandelis, Roberto Li Voti   +11 more
doaj   +1 more source