Results 181 to 190 of about 737,629 (313)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Scalable electrochemical CO₂ reduction to oxalate in a continuous flow reactor. [PDF]

Sci Rep
Dionisio D, Narváez-Romo B, Ribeiro LNBS, Silva ECN, Meneghini JR, Lopes T.   +5 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Abiotic CO₂ reduction promoted by carbonate and phyllosilicate minerals on the primitive seafloor. [PDF]

Nat Commun
Zhong Y, Zhang N, Huan D, Low J, Daniel I, Cleaves HJ, Zhang C, Li Y, Jiang Y, Wang X, Glein CR, Li J, Bai Y, Li Y, Huang F, Qin L, Knoll AH, Hao J, Long R, Xiong Y.   +19 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Local Environmental Effects on Light-Driven CO₂ Reduction in Liposomes. [PDF]

ACS Catal
Abbas A, Jacobi R, Merker I, Müller R, Ritz NR, Kumar N, Elbeheiry HM, Sorsche D, Leopold K, González L, Pannwitz A.   +10 more
europepmc   +1 more source

Mission CO2 Reduction [PDF]

, 2014
openaire   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Structured Electrodes Induce Local pH as a Primary Determinant of CO₂ Reduction Selectivity. [PDF]

J Am Chem Soc
Zhu M, Morphet DR, Wang Y, Yan Z, Nocera DG.   +4 more
europepmc   +1 more source

Insights into the Structural Dynamics of Cu@Ag Core-Shell Nanoparticles during CO2 Reduction [PDF]

BIO Web of Conferences
Esteban Daniel Arenas, Pacquets Lien, Choukroun Daniel, Hoekx Saskia, Kadu Ajinkya, Schalck Jonathan, Daems Nick, Breugelmans Tom, Bals Sara   +8 more
doaj   +1 more source