Results 91 to 100 of about 2,176,807 (298)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Geological storage of CO2: Mechanical and chemical effects on host and seal formations [PDF]

, 2009
The socio-economic impact of global warming resulting from anthropogenic CO2 emissions has lead to much attention for carbon mitigation strategies in recent years.
Hangx, Suzanne, Subsurface mineralization of CO2: rate of CO2 mineralization and geochemical effects on host and seal formations, Influence of fluids on the deformation behaviour of crustal and upper mantle rocks, Experimental rock deformation   +3 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Evaluation of CO2 storage performance in deep saline aquifers in Shaqiu Block of Junggar Basin

Youqi dizhi yu caishoulu
CO2 geological storage in deep saline aquifers， due to its huge storage potential， is regarded as an important technology for achieving large-scale CO2 emission reduction.
LI Kai, XU Chongjun, LEI Hongwu, HU Xiaodie, XIANG Xiaoling, BAI Bing, YUAN Yilong   +6 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Research on carbon dioxide geological storage and utilization: progress and prospects

Reli fadian
Carbon capture, utilization and storage (CCUS) is a key technology to mitigate the impact of CO2 emissions on the environment, and CO2 geological storage and utilization is an important part of CCUS.
FANG Jie, LEI Hongwu, SHI Junjie, BAI Bing, LI Nana, ZHAO Yanqiang   +5 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Technology and practice of CO2 capture and storage from Yanchang Petroleum

Meitan kexue jishu
Through the innovative combination of CO2 capture in the coal chemical industry and oil reservoir CO2 storage, Yanchang Petroleum has realized multiple benefits such as clean utilization of coal, carbon emission reduction, and crude oil production ...
Xiangzeng WANG, Hong YANG, Fangna LIU, Haiwen HU, Chaoyue LI, Ying LIU, Quansheng LIANG, Chunwei ZHANG   +7 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

An International Regulatory Framework for Risk Governance of Carbon Capture and Storage [PDF]

This essay was prepared as part of a workshop on carbon capture and sequestration held by the International Risk Governance Council (IRGC) in Washington, DC, from March 15–16, 2007.
Torvanger, Asbjørn, Gode, Jenny, Vajjhala, Shalini   +2 more
core