Results 101 to 110 of about 1,641,615 (299)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2020 Synthesis of cyclic carbonates via cycloaddition reaction by means of CO2 and epoxides has been thought as an effective method for relieving global warming together with resource shortage.
Su, Qian +6 more
core +1 more source
Renewable production of nylon precursors from lignin
Cell Reports SustainabilitySummary: Cyclohexanone and cyclohexanol are critical monomeric precursors in the production of nylon 6 and nylon 66, which are conventionally sourced from petroleum.
Kaile Li +9 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Research Progress on Carbon Capture and Utilization Technology in Steel Industry
发电技术ObjectivesThe control of greenhouse gas emissions, mainly CO2, under the “carbon peak and carbon neutrality” target has received high attention. In 2023, China’s CO2 emissions ranked first in the world, with 12.6 billion tons.
SHAO Yan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Research Review of CO2 Capture, Utilization and Storage Technology in Zhejiang Province
南方能源建设[Introduction] The green and low-carbon transformation and industrial restructuring under the premise of energy security is a serious challenge faced by Zhejiang Province to achieve its "carbon peaking and carbon neutrality" goals.
Chenglong HOU +6 more
doaj +1 more source