MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Dual-functional Ni and Co oxide-doped carbon nanocomposite: an effective catalyst for electrochemical water splitting and CO<sub>2</sub> utilization. [PDF]
Zia M +8 more
europepmc +1 more source
Advanced Chemical Looping Materials for CO₂ Utilization: A Review. [PDF]
Hu J, Galvita VV, Poelman H, Marin GB.
europepmc +1 more source
Towards CO2 circularity : feasibility and limits of CO2 capture and utilization
Vers la circularité du CO2 : Faisabilité et limites du captage et de la valorisation du CO2 Le dioxyde de carbone est l’un des principaux contributeurs au changement climatique mondial, ce qui motive les avancées dans sa capture (CC) ainsi que sa valorisation (CCU).
openaire +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Material needs for power-to-X systems for CO<sub>2</sub> utilization require a life cycle approach. [PDF]
Sahu AK +7 more
europepmc +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Multi-omics analysis reveals the genetic basis for rapid CO<sub>2</sub> utilization in the acetogenic bacterium <i>Sporomusa sphaeroides</i> KIAC. [PDF]
Bae J +13 more
europepmc +1 more source
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source

