Results 341 to 350 of about 928,460 (400)

Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks. [PDF]

Front Immunol
Yu F, Sun C, Li L, Yu X, Shen S, Qiang H, Wang S, Li X, Zhang L, Liu Z.   +9 more
europepmc   +1 more source

3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study identifies 3‐hydroxy‐kynurenamine (3‐HKA) as a significantly downregulated tryptophan metabolite after ischemic stroke. Supplementation with 3‐HKA enhances long‐term neurological recovery by promoting vascular remodeling, through which the regulation of astrocyte A1/A2 transition is mediated by inhibiting AIM2 inflammasome activation.
Jun‐Min Chen, Guang Shi, Lu‐Lu Yu, Wei Shan, Jing‐Yu Sun, An‐Chen Guo, Jian‐Ping Wu, Tie‐Shan Tang, Xiang‐Jian Zhang, Qun Wang   +9 more
wiley   +1 more source

Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 14, April 10, 2025.
By combining snRNA‐seq and bulk RNA‐seq, this study identified key hepatocyte subtypes, genes, and pathways in HCC. It established a Quantile Distribution Model, providing potential targets for HCC diagnosis and treatment. It categorized HCC into metabolic, inflammatory, and matrix classes, each with sensitive drugs identified.
Huanhou Su, Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Wei Meng, Cui Lv, Yuting Chen, Zebin Wen, Xu Li, Yongzhang Wu, Changtai Xiao, Jian Yang, Jiameng Lu, Xingguang Luo, Yan Chen, Paul KH Tam, Chuanjiang Li, Haitao Sun, Xinghua Pan   +18 more
wiley   +1 more source

Exploring the efficacy of recombinant human pro-urokinase in catheter-directed thrombolysis for acute lower extremity deep venous thrombosis patients. [PDF]

BMC Cardiovasc Disord
Ma T, Li C, Song G, Yao S.
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis. [PDF]

Front Cell Infect Microbiol
Abudouleh E, Owaidah T, Alhamlan F, Al-Qahtani AA, Aljowaie RM, Al-Ghnnam F, Fe Bohol M, Al-Qahtani AA.   +7 more
europepmc   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Effect of Tofacitinib on Hemostasis in Patients with Ulcerative Colitis: A Comparative Ex Vivo Study. [PDF]

Pharmaceuticals (Basel)
Sánchez-Sánchez C, Suarez-Trujillo F, Ramírez C, Soleto I, Mercado J, Orejudo M, Martínez PJ, Rubio Collado C, Orts M, Rubio Franco MJ, Planas A, Acedo N, Butta N, Chaparro M, Gisbert JP, Baldán-Martín M.   +15 more
europepmc   +1 more source

The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Briefly, patients with ASCVD have a reduced abundance of B. ovatus in their feces. Oral administration of live B. ovatus attenuated atherosclerosis. Specifically, B. ovatus restores the expression of intestinal barrier proteins and improves bile acid metabolism, while producing the tryptophan metabolite IAA restores the M1/M2 polarisation balance by ...
Wu Liu, Jingyu Wang, Heng Yang, Congcong Li, Wanqi Lan, Tingtao Chen, Yanhua Tang   +6 more
wiley   +1 more source