Results 351 to 360 of about 928,460 (400)

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Optimization and Preparation of Polysaccharide-Protamine Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing. [PDF]

Mar Drugs
Mei D, Cheng F, Li Y, Zhang S, Zhao X, Zhao Y.   +5 more
europepmc   +1 more source

Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The strategy of ultra‐small Pd loaded covalent organic framework combined with NIR irradiation (TP@Pd+NIR) is developed to reprogram lung redox homeostasis for the synergistic enhancement of acute lung injury immunotherapy via ROS scavenging, M2 directional polarization, NF‐κB pathway inhibition as well as tissue repair acceleration.
Doudou Lei, Lin Liao, Tao Qin, Xiaoxuan Guan, Kunpeng Duan, Zhiwei Gao, Weiqian Jin, Mingjing Yin, Ke Zhang, Yan Liu, Yin Chen, Huyang Gao, Jiaxiao Li, Feifei Huang, Wenjing Liu, Chengde Xia, Bailei Wang, Hualin Huang, Shengqiu Lv, Qiang Zhi, Jiahao Huang, Ming Gao, Junyu Lu   +22 more
wiley   +1 more source

Clinical significance and immune landscape analyses of the coagulation-related gene signatures in gastric cancer. [PDF]

J Cancer
Yu Y, Liu D, Xie J, Feng Z, Huang X, Li H, Xie Y, Zhou X.   +7 more
europepmc   +1 more source

Extreme Tolerance of Nanoparticle‐Protein Corona to Ultra‐High Abundance Proteins Enhances the Depth of Serum Proteomics

Advanced Science, Volume 12, Issue 11, March 20, 2025.
The intrinsic tolerance of NPC to ultra‐high abundance plays an important role in serum NPC formation for enhanced proteomic depth, validated through spike‐in protein assay. The NPC formation is the result of a balance of protein binding affinity, concentration, and protein‐protein interactions.
Qiqi Liu, Mengjie Wang, Xin Dai, Shuangqin Li, Haoxiang Guo, Haozhe Huang, Yueli Xie, Chenlu Xu, Yuan Liu, Weihong Tan   +9 more
wiley   +1 more source

Evaluating the efficacy of low-molecular-weight heparin in managing umbilical artery thrombosis during pregnancy: does it offer therapeutic benefits? [PDF]

Front Med (Lausanne)
Zhao P, Lu Y, Liu S, Zhang L, Chen C, Yang X.   +5 more
europepmc   +1 more source

Correction to: Tissue Remodeling for a More Homogenous Ablation in Transoral Outlet Reduction Using Suturing and Noncontact Argon Plasma Coagulation. [PDF]

ACG Case Rep J
Sierra L, Chatterjee A, Khurana A, Prado R, Patel R, Firkins SA, Simons-Linares R.   +6 more
europepmc   +1 more source

Integrated analysis and experimental validation reveal the prognostic and immunological features associated with coagulation in hepatocellular carcinoma. [PDF]

Sci Rep
Qu G, Liu K, Xu W, Li D.
europepmc   +1 more source

RETRACTION: Molecular Mechanism Whereby Paraoxonase-2 Regulates Coagulation Activation Through Endothelial Tissue Factor in Rat Haemorrhagic Shock Model. [PDF]

Int Wound J
europepmc   +1 more source