Results 271 to 280 of about 3,187,926 (385)

Relationship between Dose, Factor IX Activity Levels and Bleeding Probability for rIX‐FP Prophylaxis in Hemophilia B: A Repeated Time‐to‐Event Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
In hemophilia B, pharmacokinetic (PK)‐guided dosing of extended half‐life factor IX (EHL‐FIX) concentrates can secure targeted FIX exposure. Target FIX activity levels in plasma should be individually set primarily taking bleeding tendency into account, alongside the presence of target joints, physical activity, and preferred dosing schedules. In other
Sjoerd F. Koopman   +4 more
wiley   +1 more source

RAB19, SERPINB9P1, and Pancreatitis in Patients Taking Azathioprine in Routine Clinical Practice: Genome and Transcriptome‐Wide Association Studies

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Azathioprine is used to treat several inflammatory and autoimmune diseases. However, its use is limited by serious adverse events, including acute pancreatitis. Prior studies have found an association between the HLA region and thiopurine‐induced acute pancreatitis (TIAP); however, in clinical practice, many patients with pancreatitis do not meet this ...
Shailja C. Shah   +16 more
wiley   +1 more source

The Cenomanian–Turonian boundary interval in the Western Canada Foreland Basin: Stratigraphy, geochemistry, geochronology and sea‐level changes recorded in expanded and condensed clastic successions

open access: yesThe Depositional Record, EarlyView.
Shallow‐marine mudstone of the Cretaceous Kaskapau Formation in the British Columbia foredeep preserves a 185 m thick record of OAE2. The organic carbon‐isotope and osmium‐isotope excursions can be correlated in detail with other Cenomanian–Turonian boundary sections around the world.
A. Guy Plint   +12 more
wiley   +1 more source

Ichnological discrimination of hemipelagic‐dominated slope versus basin‐floor mudstones: Insights from early Viséan successions of a distally steepened ramp, northern Iran

open access: yesThe Depositional Record, EarlyView.
This study integrates sedimentological and ichnological data to reveal the depositional processes and environmental conditions of deep‐water muddy gravity flows in the Mobarak Formation. It highlights distinct ichnocoenoses and bioturbation patterns, offering insights into basin‐floor versus slope mudstones and their implications for hydrocarbon ...
Aram Bayet‐Goll   +2 more
wiley   +1 more source

Spontaneous splenic rupture in a patient with factor XIII deficiency: A case report. [PDF]

open access: yesRadiol Case Rep
Zepeda Torres JM   +9 more
europepmc   +1 more source

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