Results 41 to 50 of about 191,615 (285)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

The association between abnormal coagulation testing in preeclampsia, adverse pregnancy outcomes, and placental histopathology

Hypertension in Pregnancy, 2019
Objective: We aimed to determine whether abnormal coagulation laboratory testing results in preeclampsia, are associated with adverse pregnancy outcomes and placental histopathology lesions.
Ohad Feldstein, Michal Kovo, Ori Tal, Michal Braunstein, Ehud Grinstein, Letizia Schreiber, Jacob Bar, Eran Weiner   +7 more
doaj   +1 more source

Lupus Antibody Mimicking Reduced Plasmatic Coagulation in a Patient With Atrial Fibrillation and Ischemic Stroke

Frontiers in Neurology, 2020
Background: Lupus anticoagulant (LA) owns procoagulant properties in vivo and prolongs phospholipid-dependent clotting times in vitro. The prolonged in vitro clotting time can be misinterpreted as a bleeding disorder.
Aydin Huseynov, Aydin Huseynov, Verena Haselmann, Maximillian Kittel, Thomas Bertsch, Angelika Alonso, Michael Neumaier, Martin Borggrefe, Martin Borggrefe, Ursula Hoffmann, Ursula Hoffmann   +10 more
doaj   +1 more source

Update on laboratory testing and hemostasis assessment in patients receiving direct oral anticoagulants (DOACs)

Thrombosis Update, 2021
Direct oral anticoagulants (DOACs) have been established and already registered worldwide for clinical use. Contrary to vitamin K antagonists, their mode of action is based on the direct inhibition of the single coagulation enzymes factor Xa or IIa. Even
Vasilios Perifanis, Nikolaos Neokleous, Dimitrios A. Tsakiris   +2 more
doaj   +1 more source

A novel multifunctional biomedical material based on polyacrylonitrile:preparation and characterization [PDF]

, 2016
Wet spun microfibers have great potential in the design of multifunctional controlled release materials. Curcumin (Cur) and vitamin E acetate (Vit. E Ac) were used as a model drug system to evaluate the potential application of the drug-loaded microfiber
Bremner, David H., Li, He-yu, Shi, Qi-quan, Wu, Huan-ling, Wu, Jun-zi, Xiao, Rui-qiu, Zhu, Li-min   +6 more
core   +3 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey

TH Open, 2020
Introduction Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population. Methods Young Saudi
Khalid A. AlSaleh, Nouf Al-Numair, Ayman AlSuliman, Mohammed Zolaly, Abdul Majeed Albanyan, Nouf AlOtaishan, Esra Abudouleh, Nervana Bayoumy, Ahmad Tarawah, Faisal AlZahrani, Faisal AlAllaf, Abdul kareem AlMomen, Raihan Sajid, Tarek M. Owaidah   +13 more
doaj   +1 more source

Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes

Frontiers in Medicine, 2021
The Acute Respiratory Distress Syndrome (ARDS) has caused innumerable deaths worldwide since its initial description over five decades ago. Population-based estimates of ARDS vary from 1 to 86 cases per 100,000, with the highest rates reported in ...
Samantha A. Livingstone, Samantha A. Livingstone, Karin S. Wildi, Karin S. Wildi, Karin S. Wildi, Heidi J. Dalton, Asad Usman, Katrina K. Ki, Katrina K. Ki, Margaret R. Passmore, Margaret R. Passmore, Gianluigi Li Bassi, Gianluigi Li Bassi, Gianluigi Li Bassi, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser   +17 more
doaj   +1 more source

Influence of vitamin K antagonist treatment on activated partial thromboplastin time [PDF]

, 2015
A
Devreese, Katrien, MULLIEZ, SYLVIE, Van den Bogaert, Julie   +2 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source