Results 111 to 120 of about 21,153 (309)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Anytime coalition structure generation on synergy graphs
, 2014 We consider the coalition structure generation (CSG) problem on synergy graphs, which arises in many practical applications where communication constraints, social or trust relationships must be taken into account when forming coalitions.
Ramchurn, Sarvapali D. +9 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Multiple Objective Robot Coalition Formation
Journal of Intelligent Systems, 2011 In multiple robot systems, the problem of allocation of complex tasks to heterogeneous teams of robots, also known as the multiple robot coalition formation problem, has begun to receive considerable attention.
Agarwal Manoj +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Novel Heuristics for Coalition Structure Generation in Multi-Agent Systems
A coalition is a set of self-interested agents that agree to cooperate for achieving a set of goals. Coalition formation is an active area of research in multi-agent systems nowadays.
Prugel-Bennett, Adam +1 more
core
Coalition Structure Generation: Dynamic Programming Meets Anytime Optimisation
, 2008 Coalition structure generation involves partitioning a set of agents into exhaustive and disjoint coalitions so as to maximize the social welfare. What makes this such a challenging problem is that the number of possible solutions grows exponentially as ...
Jennings, Nick, Rahwan, Talal
core
Modern WTO coalitions and groups in the formation of the global trade policy [PDF]
International Economic Policy, 2010 It reveals the nature of the concepts «coalition» and «informal group» in the framework of the international economic organizations, realizes their comparative analysis and classifies the coalitions based on the circle of the covered activity directions,
Tetyana Tsyhankova, Hanna Solodkovska
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source