Results 191 to 200 of about 269,399 (299)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Ultrasonography or Radiography for Suspected Pediatric Talocalcaneal Coalition. [PDF]

J Pediatr Orthop
Li XT, Shen XT, Wu X.
europepmc   +1 more source

Coalitional stability in structured environments [PDF]

Summarization: In many real-world settings, the structure of the environment con- strains the formation of coalitions among agents. Therefore, ex- amining the stability of formed coalition structures in such set- tings is of natural interest. We address this by considering core- stability within various models of cooperative games with struc- ture ...
Χαλκιαδακης Γεωργιος(http://users.isc.tuc.gr/~gchalkiadakis), Chalkiadakis Georgios(http://users.isc.tuc.gr/~gchalkiadakis), Evangelos Markakis(), Nicholas R. Jennings()   +3 more
openaire  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Political economy of adolescent mental health and well-being globally. [PDF]

Health Res Policy Syst
Biermann O, Shawar YR, Shiffman J, Brown SL, Bain M, Shire I, Baird S, Collins PY, Requejo JH, Mensa-Kwao A, Tomlinson M, George A, Kumar M, Aranda Z, Tamambang R, Omigbodun O, Peterson SS, Claeson M.   +17 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Community-level perceptions of housing services for people with opioid use disorder: a qualitative analysis of community stakeholders in the HEALing communities study. [PDF]

Subst Abuse Treat Prev Policy
Dsouza N, Russo M, Goddard-Eckrich D, Hernandez D, Sabounchi N, Lounsbury D, Fowler P, Benjamin SN, Campbell ANC, Dasgupta A, El-Bassel N, Gilbert L.   +11 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Reciprocal Innovation in Action: Adapting a Community-Based Care Model for Pregnant and Parenting Women in Kenya to Indiana. [PDF]

Ann Glob Health
Scanlon M, Dumornay D, Litzelman DK, Ikemeri JE, Jumah A, Jean-Baptiste L, Jackson J, Joseph MN, Christoffersen-Deb A, Songok J, Ruhl LJ.   +10 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source