Results 111 to 120 of about 32,663 (321)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

A RARE PRESENTATION OF COARCTATION OF AORTA AS HEMORRHAGIC STROKE IN 22 YEARS OLD MALE: A CASE REPORT

National Journal of Medical Research, 2020
Spontaneous intracerebral hemorrhage in young adult is rare phenomena. most of them are due to rupture of arteriovenous malformation and cavernous angioma. Here we are reportinga rare presentation of aortic coarctation in adult as stroke.
Vivek Singh, Kshitij Prasad, Pankaj Kumar Singh, Deeksha Singh, Brijesh Kumar Singh, Ranjan Bhattnagar   +5 more
doaj  

Neurofibromatosis Type 1 Complicated by Atypical Coarctation of the Thoracic Aorta

Case Reports in Pediatrics, 2013
Neurofibromatosis type 1 (NF1) is a relatively common autosomal dominant genetic disorder with a prevalence of 1 in 3,000 (0.03%) at birth. Clinical features are café-au-lait macules, intertriginous freckling, dermal neurofibroma, iris hamartoma (Lisch ...
Masato Kimura, Shuhei Kakizaki, Kengo Kawano, Shinichi Sato, Shigeo Kure   +4 more
doaj   +1 more source

Surgical Treatment Methods of Post-coarctation Aneurysms of Aorta

Український журнал серцево-судинної хірургії, 2019
Introduction. Aortal coarctation is one of the most studied conditions of heart congenital defects, which comprises from 7% to 10% of all congenital heart defects. During many years the various treatment strategies were used.
I. M. Kravchenko, V. I. Kravchenko, Yu. Tarasenko, B. V. Cherpak, S. G. Klymenko, V. V. Lazoryshynets   +5 more
doaj   +1 more source

Circumaortic Left Brachiocephalic Vein with Coarctation of Aorta. [PDF]

Anatol J Cardiol, 2023
Subramanian P, Sharma A, Singhal M.
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Mild-aortic syndrome: a cause of recurrent abdominal pain [PDF]

, 2016
Mid-aortic syndrome (MAS) is a rare clinical entity that is characterized by coarctation involving the distal thoracic and/or abdominal aorta and its major branches accounting for 0.5–2% of all cases of coarctation of the aorta (1).
Abdul Latiff, Haifa, Sing, Alan, Yubbu, Putri   +2 more
core  

Taussig-Bing Malformation, Coarctation of the Aorta, and Reversed Patent Ductus Arteriosus [PDF]

, 1970
Anne L. Wedemeyer, Russell V. Lucas, Aldo R. Castañeda   +2 more
openalex   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

Clinical Endocrinology, EarlyView.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri, Sushil Yewale, Hannah Hickingbotham, Cara Williams, Mohamed Shalaby, Julie Alderson, Julie Park   +6 more
wiley   +1 more source