Results 91 to 100 of about 32,390 (304)

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Treating a 20 mm Hg Gradient Alleviates Myocardial Hypertrophy in Experimental Aortic Coarctation [PDF]

, 2017
Background Children with coarctation of the aorta (CoA) can have a hyperdynamic and remodeled left ventricle (LV) from increased afterload. Literature from an experimental model suggests the putative 20 mm Hg blood pressure gradient (BPG) treatment ...
Friehs, Ingeborg, Harmann, Leanne, LaDisa, John F., Samyn, Margaret M., Wendell, David C.   +4 more
core   +1 more source

Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective We aimed to characterize the fetal features across gestation and describe genotype‐phenotype correlations for pregnancies with fetal RASopathies that were more severely affected as they presented with at least one abnormal fluid collection.
Natalie B. Gulrajani, John Boscardin, Billie R. Lianoglou, Katie Tick, Carmen M. A. Santoli, Kristen A. Miller, Angie C. Jelin, Lorraine Dugoff, Rose Giardine, Cori Feist, Rachel Pilliod, Stephanie Dukhovny, Kelly Gilmore, Neeta L. Vora, Aisling Murphy, Peter N. Robinson, Mary E. Norton, Teresa N. Sparks   +17 more
wiley   +1 more source

Prognostic implications of residual mild coarctation gradient after interventional repair

The Journal of Clinical Hypertension
There is limited data on the prognostic implications of residual mild coarctation (RMC) in patients with repaired native coarctation of the aorta (CoA).
Wenhao Zhu, Zhiyuan Xia, Congcong Zhou, Junyi Wan, Jingyu Wang, Yihang Li, Jingnan Zhang, Michael Henein, Fang Fang, Gejun Zhang   +9 more
doaj   +1 more source

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source

A Case of Severe Asymptomatic Aortic Coarctation in an Adult Female

Case Reports in Cardiology, 2011
Coarctation of the aorta is typically a disease of childhood and early adulthood, and there is a reduced life expectancy in patients who have not undergone correction.
Spyros Tsikrikas, Charalampos Charalampous, Konstantinos P. Letsas   +2 more
doaj   +1 more source

A statistical shape modelling framework to extract 3D shape biomarkers from medical imaging data: assessing arch morphology of repaired coarctation of the aorta [PDF]

, 2016
Background Medical image analysis in clinical practice is commonly carried out on 2D image data, without fully exploiting the detailed 3D anatomical information that is provided by modern non-invasive medical imaging techniques.
Andrew M. Taylor, Claudio Capelli, Giovanni Biglino, Hopewell N. Ntsinjana, Jan L. Bruse, Kristin McLeod, Maxime Sermesant, null null, Silvia Schievano, Tain-Yen Hsia, Xavier Pennec   +10 more
core   +5 more sources

Age‐Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice

Pediatric Discovery, EarlyView.
This study examined the relationship between aortic arch stiffness and lung function in aging mice. Multiple linear regression modeling showed moderate to strong correlations between the rise in aortic arch stiffness and changes in lung function as the mice progressively aged.
Ayman Isbatan, Samuel M. Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan A. Marian, Richard D. Minshall, Jie Tian, Irena Levitan, Jiwang Chen   +10 more
wiley   +1 more source

Exercise Catheterization for Hemodynamic Evaluation of Adults with Coarctation of the Aorta [PDF]

, 2022
Irene Martín de Miguel, C. Charles Jain, Alexander C. Egbe, Jason H. Anderson, Heidi M. Connolly, William R. Miranda   +5 more
openalex   +1 more source

Impaired Poststenotic Aortic Pulsatility After Hemodynamically Ideal Coarctation Repair in Children [PDF]

, 2018
Using echocardiographic quantification of aortic pulsatility distal to the site of the surgical anastomosis, we evaluated whether the preoperatively impaired poststenotic aortic pulsatility returned to normal after repair of coarctation with a ...
Berdat, P., Carrel, T., Pfammatter, J.
core