Results 261 to 270 of about 2,738,317 (296)

Mib2 Regulates Lipid Metabolism in Heart Failure With Preserved Ejection Fraction via the Runx2–Hmgcs2 Axis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 7, April 2025.
ABSTRACT Obesity and the mismanagement of lipids significantly contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, the underlying molecular mechanisms that regulate the metabolic changes and disruptions in lipid balance within HFpEF remain to be fully understood.
Zhulan Cai, Shunyao Xu, Xiaohua Xiao, Chen Liu, Lingyun Zu   +4 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

On the mechanisms of brain blood flow regulation during hypoxia

The Journal of Physiology, Volume 603, Issue 8, Page 2263-2280, 15 April 2025.
Abstract figure legend Schematic illustration of key hypothesized mechanisms mediating the cerebrovascular response to hypoxia, suggested by the results of studies included in this analysis. Abstract The brain requires an uninterrupted supply of oxygen and nutrients to support the high metabolic needs of billions of nerve cells processing information ...
Alexander Mascarenhas, Alice Braga, Sara Maria Majernikova, Shereen Nizari, Debora Marletta, Shefeeq M. Theparambil, Qadeer Aziz, Nephtali Marina, Alexander V. Gourine   +8 more
wiley   +1 more source

Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague–Dawley rats

Physiological Reports, Volume 13, Issue 7, April 2025.
Abstract The mechanisms of sex differences in cerebrovascular function are not well understood. In this study, we determined whether sex differences in middle cerebral artery (MCA) reactivity are accompanied with changes in cerebral or systemic arterial resistance and stiffness in young adult Sprague–Dawley (SD) rats.
Jonathan W. Ray, Xuming Sun, Nildris Cruz‐Diaz, Victor M. Pulgar, Liliya M. Yamaleyeva   +4 more
wiley   +1 more source

Un-diagnosed coarctation of the aorta in a 27-year-old adult with a rare presentation: a rare case report. [PDF]

Ann Med Surg (Lond)
Shhada E, Saleh M, Kf Alghazal MA, Wasel N.   +3 more
europepmc   +1 more source

Mechanistic evaluation of ertugliflozin in patients with type 2 diabetes and heart failure

Physiological Reports, Volume 13, Issue 7, April 2025.
HF patients exhibit counterregulatory adaptations to tubular sodium handling. SGLT2 inhibition shifts systemic volume toward a state of euvolemia, potentially lowering the risk of worsening HF. Abstract The effect of sodium‐glucose cotransporter‐2 (SGLT2) inhibitor ertugliflozin on fluid volume and kidney function was assessed in patients with type 2 ...
Yuliya Lytvyn, Rosalie A. Scholtes, Eva M. Boorsma, Vikas S. Sridhar, Luxcia Kugathasan, Hongyan Liu, Leif E. Lovblom, Louis Handoko, Charlotte M. Mosterd, John S. Floras, Kevin Burns, Tosin Osuntokun, Adriaan Voors, Daniel H. van Raalte, Hiddo J. L. Heerspink, David Z. I. Cherney   +15 more
wiley   +1 more source

Association between peripheral and coronary microvascular function and the impact of myocardial bridging

Physiological Reports, Volume 13, Issue 8, April 2025.
Abstract The reactive hyperemia index (RHI) is a marker of peripheral microvascular function influenced by both endothelium‐dependent and independent mechanisms. Myocardial bridging (MB) may impact coronary microvascular function, but its effect on the relationship between RHI and coronary microvascular function remains unclear. In this cross‐sectional
Takumi Toya, Shotaro Yoshida, Kazuhiko Kuinose, Shun Akai, Tsukasa Urushima, Kaoru Naito, Masanori Oobori, Yusei Nakashima, Akira Miyauchi, Yuji Nagatomo, Takeshi Adachi   +10 more
wiley   +1 more source