Results 61 to 70 of about 198,236 (297)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A conversion disorder [PDF]

, 2015
Interrogating the relationship between reading, writing and ‘conversion disorder’, this creative-critical essay explores the eversion of the glove in the work of Woolf, Genet, Freud and Derrida.
Jackson, S
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Metafora i jej rola w portretowaniu postaci w Źwierzyńcu Mikołaja Reja

Meluzyna: dawna literatura i kultura, 2017
The study is dedicated to the image creation of the characters in “Źwierzyniec” (“Bestiary”) by Mikołaj Rej (1505–1569€), based on the metaphors. This article focuses on determining the role of metaphors in portraying representatives of the nobility ...
Krystian Słomka vel Słomiński Słomka vel Słomiński
doaj   +1 more source

“Have the Menacing Alcaean Muses Blown the War Trumpets Again?” Two Versions of Jacobus Wallius’ Ode to Mathias Casimirus Sarbieviu [PDF]

, 2015
Item does not contain fulltextThe article discusses the Neo-Latin eulogy by the Flemish Jesuit Jacobus Wallius (1599-1690) to the famous Pole Mathias Casimirus Sarbievius (1595-1640).
Hulsenboom, Paul
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Ivan Tomko Mrnavić and His Coat of Arms: Self-presentation of an Illyrian Noble

Radovi Instituta za Povijest Umjetnosti, 2018
The article discusses the coat of arms of Ivan Tomko Mrnavić as a visual sign of his self-presentation. Examples of Mrnavić’ s coat of arms are presented and the contexts of their use interpreted, such as frontispieces, title pages, or seals.
Daniel Premerl
doaj  

The symbolic dimension of the city : the presence of a dragon in the urban space of Krakow [PDF]

, 2018
Praca porusza problematykę symbolicznego wymiaru miasta tworzonego z podsystemu urbanistycznego i społecznego. Miasto i jego krajobraz są tu rozumiane jako system znaków funkcjonujący w dwóch odrębnych, zależnych od siebie porządkach rzeczywistości ...
Angiel, Marek, Pietrzak, Małgorzata
core   +1 more source