Results 31 to 40 of about 5,394 (249)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Rural heraldic symbols adopted in the Republic of Moldova in 2017-2018
Tyragetia, 2020 Regarding the rural heraldic and vexillological projects, the years 2017-2018 were some prolific ones for the Republic of Moldova. In this article are presented, mentioned in their order of registration in the General Armorial of the Republic of Moldova,
Silviu Andrieş-Tabac
doaj
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The Shields that Guard the Realms of Men: Heraldry in Game of Thrones
Genealogy, 2018 The vast popularity of the Game of Thrones franchise has drawn a new and diverse audience to the fantasy genre. Within the pseudo-medieval world created by G.R.R.
Mat Hardy
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
La cartographie héraldique de Frotier de la Messelière
Les Cahiers de l'École du Louvre, 2023 In 1960 Henri Frotier de la Messelière bequeathed 286 volumes of his notes and drawings on the monumental and heraldic heritage and the history of the department’s nobility to the Côtes-d’Armor archives.
Laurent Hablot
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Die ontwikkeling van die Brakpanse munisipale wapen 1920-1966
ContreeThe municipal coat of arms approved by the Brakpan Town Council in 1920 was not of sound heraldic design. This, however, only became an issue when the Heraldry Society of Southern Africa called upon the Council to eliminate the heraldic defects in it, so
F.J. Nöthling
doaj +1 more source