Results 31 to 40 of about 6,846 (287)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Dictionary of British Arms [PDF]
, 2009 This is the third of a four-volume collection of British heraldic arms, arranged alphabetically according to their designs and covering the period before 1530. Listed in this volume are entries from Chief to Fess.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Dictionary of British Arms [PDF]
, 2014 This is the fourth of a four-volume collection of British heraldic arms, arranged alphabetically according to their designs and covering the period before 1530.
core +1 more source
Bibliotheca Lituana, 2019 Heraldry and its research have deep traditions in Europe, making it a certain focus of attention among researchers. The interest in this field in Lithuania is a more recent phenomenon.
Gabrielė Jasiūnienė
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Dictionary of British Arms [PDF]
, 1996 This is the second of a four-volume collection of British heraldic arms, arranged alphabetically according to their designs and covering the period before 1530. Listed within this volume are entries from Bend to Chevron.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Dictionary of British Arms [PDF]
, 1992 This is the first of a four-volume collection of British heraldic arms, arranged alphabetically according to their designs and covering the period before 1530. Listed in this volume are entries from Anchor to Bend. This book will help readers to identify
core +1 more source