Results 11 to 20 of about 69 (59)

Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alpha‐synuclein (αSyn) seed amplification assay (SAA) enables in vivo study of αSyn but remains underexplored in Down syndrome‐associated Alzheimer's disease (DSAD). METHODS We analyzed αSyn‐SAA in cerebrospinal fluid (CSF) from 270 adults with Down syndrome, from the Down Alzheimer Barcelona Neuroimaging Initiative and from the ...
Bernhardt AM, Rodríguez-Baz Í, Aldecoa I, Arranz J, Arriola-Infante JE, Maure-Blesa L, Carmona-Iragui M, Longen S, Trossbach SV, Giese A, Matthias T, Benejam B, Videla L, Del Hoyo Soriano L, Barroeta I, Sanjuan A, Fernández S, Vaqué-Alcázar L, Rozalem Aranha M, Morcillo-Nieto AO, Nübling G, Wagemann O, Stockbauer A, Tondo M, Bejanin A, Lleó A, Alcolea D, Molina-Porcel L, Fortea J, Levin J.   +29 more
europepmc   +2 more sources

Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI. [PDF]

Alzheimers Dement
Abstract BACKGROUND Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with ...
Aranha MR, Montal V, van den Brink H, Pegueroles J, Carmona-Iragui M, Videla L, Maure Blesa L, Benejam B, Arranz J, Valldeneu S, Barroeta I, Fernández S, Ribas L, Alcolea D, González-Ortiz S, Bargalló N, Biessels GJ, Blesa R, Lleó A, Coutinho AM, Leite CC, Bejanin A, Fortea J.   +22 more
europepmc   +2 more sources

Project Manual – CoBraD RWD, Updated MES-CoBraD Protocols and Quality and Quantity (Q&Q) Evaluation

, 2021
The current Project Manual (PM) aims to be a continuously updated reference on (a) metrics that are assessed in people with CoBraD belonging to the above categories of RWD, (b) their systematic and standardised quality requirements, and (c) the agreed upon multisource RWD acquisition protocols. The PM reflects the foundation of the project’s scientific
  +9 more sources

Special Issue: Abstracts of the 11^th Congress of the European Academy of Neurology, Helsinki, Finland. [PDF]

Eur J Neurol
European Journal of Neurology, Volume 32, Issue S1, June 2025.
europepmc   +2 more sources

Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

Alzheimer's &Dementia, Volume 19, Issue 11, Page 4817-4827, November 2023., 2023
Abstract Background Basal forebrain (BF) degeneration occurs in Down syndrome (DS)‐associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods We included 234 adults with DS (150 asymptomatic, 38 prodromal
Mateus Rozalem Aranha, Maria Florencia Iulita, Victor Montal, Jordi Pegueroles, Alexandre Bejanin, Lídia Vaqué‐Alcázar, Michel J. Grothe, Maria Carmona‐Iragui, Laura Videla, Bessy Benejam, Javier Arranz, Concepción Padilla, Sílvia Valldeneu, Isabel Barroeta, Miren Altuna, Susana Fernández, Laia Ribas, Natalia Valle‐Tamayo, Daniel Alcolea, Sofía González‐Ortiz, Núria Bargalló, Henrik Zetterberg, Kaj Blennow, Rafael Blesa, Thomas Wisniewski, Jorge Busciglio, A. Claudio Cuello, Alberto Lleó, Juan Fortea   +28 more
wiley   +1 more source

classecol: Classifiers to understand public opinions of nature

Methods in Ecology and Evolution, Volume 12, Issue 7, Page 1329-1334, July 2021., 2021
Abstract Human perceptions of nature, once the domain of the social sciences, are now an important part of environmental research. However, the data and tools to tackle this research are lacking or are difficult to apply. Here, we present a collection of text classifier models to identify text relevant to the broad topics of hunting and nature ...
Thomas F. Johnson, Hebe Kent, Bethan M. Hill, Georgia Dunn, Leonie Dommett, Natasha Penwill, Tom Francis, Manuela González‐Suárez   +7 more
wiley   +1 more source

MES-CoBraD D2.3 The CoBraD ethical and regulatory framework

, 2022
During the pilot data acquisition MES-CoBraD will acquire Real World Data (RWD) in accordance with the protocols established in MES-CoBraD’s Project Manual (PM). The RWD of research participants will be stored in a central database developed. Because of the sensitivity of the project’s envisaged processing activities, the responsibilities and ...
openaire   +1 more source

MES-CoBraD Website

, 2021
The D9.2 report presents and documents the design, implementation, and deployment of the MESCoBraD project website. The MES-CoBraD website is available at the following address: https://mescobrad.eu/. Following most recent practices and principles for web design, the MES-CoBraD website is presented in a modern, yet minimalistic & user-friendly ...
openaire   +3 more sources

D8.2 MES-CoBraD Validation Framework

, 2022
The MES-CoBraD Framework Evaluation and System Validation deliverable documents the evaluation framework and validation methodology of the MES-CoBraD Platform and Pilot Protocol, defining the various practices for obtaining feedback from end-users and including a set of test-cases to be executed by the end users. The final MES-CoBraD Expert System will
openaire   +1 more source

D9.4 MES-CoBraD - Online Materials

, 2021
This report, the Online Material, mainly outlines the ways that the MES-CoBraD can share the scope and results with the appropriate audiences. More specifically, all the ways that the project is visually available are outlined in this report. First of all, the website and the social media of the project are presented, because these means are the most ...
openaire   +1 more source